Purpose: 

To investigate cone density in the asymptomatic fellow eye of patients with unilateral central serous chorioretinopathy (CSCR).

Methods: 

Seventeen asymptomatic fellow eyes of patients with unilateral CSCR and 17 eyes of aged-matched and gender-matched healthy controls underwent adaptive optics ophthalmoscopy. Cone density and spacing were assessed at the fovea. Clinical and multimodal imaging findings were also recorded.

Results: 

In the CSCR group, the patient mean age was 48.9 ± 9.8 years. The mean (±SD) subfoveal choroidal thickness was 417.8 ± 125.2 µm. The foveal external limiting membrane and ellipsoid zone were intact in all patients. Adaptive optics fundus imaging showed a significant decrease in cone density at 2° of eccentricity nasal and temporal to the fovea in asymptomatic fellow eyes of patients with unilateral CSCR compared with controls (P = 0.001 and P = 0.027, respectively). No statistically significant difference in cone density was found at 4° of eccentricity nasal and temporal to the fovea between both groups.

Conclusion: 

Asymptomatic fellow eyes of patients with unilateral CSCR showed a reduced density of foveal cones in the absence of a decreased visual acuity and photoreceptor line disruption on optical coherence tomography. These results suggest that the photoreceptors could be damaged independently of the occurrence of a serous retinal detachment.

中文翻译：

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中心性浆液性脉络膜视网膜病变：使用自适应光学扫描激光检眼镜对无症状同伴眼睛进行高分辨率成像

目的： 

研究单侧中心性浆液性脉络膜视网膜病变 (CSCR) 患者无症状对侧眼的视锥细胞密度。

方法： 

单侧 CSCR 患者的 17 只无症状对侧眼和年龄匹配和性别匹配的健康对照者的 17 只眼接受了自适应光学检眼镜检查。在中央凹处评估视锥细胞密度和间距。还记录了临床和多模态成像结果。

结果： 

在 CSCR 组中，患者平均年龄为 48.9 ± 9.8 岁。平均 (±SD) 中心凹下脉络膜厚度为 417.8 ± 125.2 µ m。所有患者的中心凹外界膜和椭圆体区均完整。自适应光学眼底成像显示，与对照组相比，单侧 CSCR 患者的无症状对侧眼在鼻侧和颞侧偏心 2° 处的锥体密度显着降低（分别为 P = 0.001 和 P = 0.027 ）。两组之间在鼻侧和颞侧中央凹偏心 4° 时，锥体密度没有发现统计学上的显着差异。

结论： 

单侧 CSCR 患者的无症状对侧眼在光学相干断层扫描中显示中心凹锥体密度降低，但没有视力下降和光感受器线破坏。这些结果表明，光感受器的损伤可能与浆液性视网膜脱离的发生无关。