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The risks of using unapproved gene symbols
American Journal of Human Genetics ( IF 8.1 ) Pub Date : 2021-10-08 , DOI: 10.1016/j.ajhg.2021.09.004
Bryony Braschi 1 , Ruth L Seal 2 , Susan Tweedie 1 , Tamsin E M Jones 1 , Elspeth A Bruford 2
Affiliation  

The use of approved nomenclature in publications is vital to enable effective scientific communication and is particularly crucial when discussing genes of clinical relevance. Here, we discuss several examples of cases where the failure of researchers to use a HUGO Gene Nomenclature Committee (HGNC)-approved symbol in publications has led to confusion between unrelated human genes in the literature. We also inform authors of the steps they can take to ensure that they use approved nomenclature in their manuscripts and discuss how referencing HGNC IDs can remove ambiguity when referring to genes that have previously been published with confusing alias symbols.



中文翻译:

使用未经批准的基因符号的风险

在出版物中使用经批准的命名法对于实现有效的科学交流至关重要,并且在讨论与临床相关的基因时尤其重要。在这里,我们讨论了几个案例,其中研究人员未能在出版物中使用 HUGO 基因命名委员会 (HGNC) 批准的符号导致文献中不相关的人类基因之间的混淆。我们还告知作者他们可以采取哪些步骤来确保他们在手稿中使用经批准的命名法,并讨论引用 HGNC ID 如何在引用先前以混淆别名符号发表的基因时消除歧义。

更新日期:2021-10-09
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