Toward closed-loop drug delivery: Integrating wearable technologies with transdermal drug delivery systems,Advanced Drug Delivery Reviews

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Toward closed-loop drug delivery: Integrating wearable technologies with transdermal drug delivery systems
Advanced Drug Delivery Reviews ( IF 15.2 ) Pub Date : 2021-10-08 , DOI: 10.1016/j.addr.2021.113997
Jyothsna Manikkath ₁ , J Anand Subramony ₂

Affiliation

The recent advancement and prevalence of wearable technologies and their ability to make digital measurements of vital signs and wellness parameters have triggered a new paradigm in the management of diseases. Drug delivery as a function of stimuli or response from wearable, closed-loop systems can offer real-time on-demand or preprogrammed drug delivery capability and offer total management of disease states. Here we review the key opportunities in this space for development of closed-loop systems, given the advent of digital wearable technologies. Particular considerations and focus are given to closed-loop systems combined with transdermal drug delivery technologies.

中文翻译：

走向闭环给药：将可穿戴技术与透皮给药系统相结合

可穿戴技术的最新进展和流行以及它们对生命体征和健康参数进行数字测量的能力已经引发了疾病管理的新范式。作为可穿戴闭环系统的刺激或响应函数的药物输送可以提供实时按需或预编程的药物输送能力，并提供对疾病状态的全面管理。鉴于数字可穿戴技术的出现，我们在这里回顾了闭环系统开发领域的关键机遇。特别考虑和关注与透皮给药技术相结合的闭环系统。

更新日期：2021-10-17

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