Chronic lymphocytic leukemia (CLL) is one of the most frequent types of leukemia. It typically occurs in elderly patients and has a highly variable clinical course. Leukemic transformation is initiated by specific genomic alterations that interfere with the regulation of proliferation and of apoptosis in clonal B-cells.

中文翻译：

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慢性淋巴细胞白血病：2022 年诊断和治疗程序更新

慢性淋巴细胞白血病 (CLL) 是最常见的白血病类型之一。它通常发生在老年患者中，并且具有高度可变的临床病程。白血病转化由干扰克隆 B 细胞增殖和凋亡调节的特定基因组改变引发。