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Ten millennia of hepatitis B virus evolution
Science ( IF 44.7 ) Pub Date : 2021-10-08 , DOI: 10.1126/science.abi5658
Arthur Kocher 1, 2, 3 , Luka Papac 2, 3 , Rodrigo Barquera 2, 3 , Felix M Key 2, 4 , Maria A Spyrou 2, 3, 5 , Ron Hübler 2 , Adam B Rohrlach 2, 3, 6 , Franziska Aron 2 , Raphaela Stahl 2 , Antje Wissgott 2 , Florian van Bömmel 7 , Maria Pfefferkorn 7 , Alissa Mittnik 2, 8, 9 , Vanessa Villalba-Mouco 2, 10 , Gunnar U Neumann 2, 3 , Maïté Rivollat 2, 11 , Marieke S van de Loosdrecht 2 , Kerttu Majander 2, 12 , Rezeda I Tukhbatova 2, 13 , Lyazzat Musralina 2, 3, 14, 15 , Ayshin Ghalichi 2, 3 , Sandra Penske 2, 3 , Susanna Sabin 2 , Megan Michel 2, 3, 9 , Joscha Gretzinger 2, 3 , Elizabeth A Nelson 2 , Tiago Ferraz 2, 16 , Kathrin Nägele 2, 3 , Cody Parker 2, 17 , Marcel Keller 2, 18 , Evelyn K Guevara 2, 19 , Michal Feldman 2, 5 , Stefanie Eisenmann 2, 3 , Eirini Skourtanioti 2, 3 , Karen Giffin 2, 3 , Guido Alberto Gnecchi-Ruscone 2, 3 , Susanne Friederich 20 , Vittoria Schimmenti 21 , Valery Khartanovich 22 , Marina K Karapetian 23 , Mikhail S Chaplygin 24 , Vladimir V Kufterin 25 , Aleksandr A Khokhlov 26 , Andrey A Chizhevsky 27 , Dmitry A Stashenkov 28 , Anna F Kochkina 28 , Cristina Tejedor-Rodríguez 29 , Íñigo García-Martínez de Lagrán 30 , Héctor Arcusa-Magallón 31 , Rafael Garrido-Pena 32 , José Ignacio Royo-Guillén 33 , Jan Nováček 34, 35 , Stéphane Rottier 11 , Sacha Kacki 11, 36 , Sylvie Saintot 37 , Elena Kaverzneva 38 , Andrej B Belinskiy 39 , Petr Velemínský 40 , Petr Limburský 41 , Michal Kostka 42 , Louise Loe 43 , Elizabeth Popescu 44 , Rachel Clarke 44 , Alice Lyons 44 , Richard Mortimer 44 , Antti Sajantila 19, 45 , Yadira Chinique de Armas 46 , Silvia Teresita Hernandez Godoy 47, 48 , Diana I Hernández-Zaragoza 49, 50 , Jessica Pearson 51 , Didier Binder 52 , Philippe Lefranc 53 , Anatoly R Kantorovich 54 , Vladimir E Maslov 55 , Luca Lai 56, 57 , Magdalena Zoledziewska 58 , Jessica F Beckett 59 , Michaela Langová 41 , Alžběta Danielisová 41 , Tara Ingman 60 , Gabriel García Atiénzar 61 , Maria Paz de Miguel Ibáñez 61 , Alejandro Romero 61, 62 , Alessandra Sperduti 63, 64 , Sophie Beckett 65, 66, 67 , Susannah J Salter 65, 68 , Emma D Zilivinskaya 25 , Dmitry V Vasil'ev 69 , Kristin von Heyking 70 , Richard L Burger 71 , Lucy C Salazar 71 , Luc Amkreutz 72 , Masnav Navruzbekov 73 , Eva Rosenstock 74 , Carmen Alonso-Fernández 75 , Vladimir Slavchev 76 , Alexey A Kalmykov 39 , Biaslan Ch Atabiev 77 , Elena Batieva 78 , Micaela Alvarez Calmet 79 , Bastien Llamas 80, 81, 82 , Michael Schultz 83, 84 , Raiko Krauß 85 , Javier Jiménez-Echevarría 75 , Michael Francken 86 , Svetlana Shnaider 87 , Peter de Knijff 88 , Eveline Altena 88 , Katrien Van de Vijver 89, 90, 91 , Lars Fehren-Schmitz 92, 93 , Tiffiny A Tung 94 , Sandra Lösch 95 , Maria Dobrovolskaya 55 , Nikolaj Makarov 55 , Chris Read 96 , Melanie Van Twest 65 , Claudia Sagona 97 , Peter C Ramsl 98 , Murat Akar 99 , K Aslihan Yener 100 , Eduardo Carmona Ballestero 101, 102 , Francesco Cucca 58, 103 , Vittorio Mazzarello 103 , Pilar Utrilla 104 , Kurt Rademaker 105 , Eva Fernández-Domínguez 36 , Douglas Baird 51 , Patrick Semal 89 , Lourdes Márquez-Morfín 106 , Mirjana Roksandic 46, 107, 108 , Hubert Steiner 109 , Domingo Carlos Salazar-García 110, 111, 112 , Natalia Shishlina 22, 38 , Yilmaz Selim Erdal 113 , Fredrik Hallgren 114 , Yavor Boyadzhiev 115 , Kamen Boyadzhiev 115 , Mario Küßner 34 , Duncan Sayer 116 , Päivi Onkamo 117, 118 , Robin Skeates 36 , Manuel Rojo-Guerra 29 , Alexandra Buzhilova 23 , Elmira Khussainova 15 , Leyla B Djansugurova 15 , Arman Z Beisenov 119 , Zainolla Samashev 120, 121 , Ken Massy 122 , Marcello Mannino 123, 124 , Vyacheslav Moiseyev 22 , Kristiina Mannermaa 125 , Oleg Balanovsky 126, 127, 128 , Marie-France Deguilloux 11 , Sabine Reinhold 129 , Svend Hansen 129 , Egor P Kitov 25, 119 , Miroslav Dobeš 41 , Michal Ernée 41 , Harald Meller 20 , Kurt W Alt 130, 131, 132 , Kay Prüfer 2, 3 , Christina Warinner 2, 3, 133 , Stephan Schiffels 2, 3 , Philipp W Stockhammer 2, 3, 122 , Kirsten Bos 2, 3 , Cosimo Posth 2, 5 , Alexander Herbig 2, 3 , Wolfgang Haak 2, 3, 134 , Johannes Krause 2, 3 , Denise Kühnert 1, 2, 3, 135
Affiliation  

Hepatitis B virus (HBV) has been infecting humans for millennia and remains a global health problem, but its past diversity and dispersal routes are largely unknown. We generated HBV genomic data from 137 Eurasians and Native Americans dated between ~10,500 and ~400 years ago. We date the most recent common ancestor of all HBV lineages to between ~20,000 and 12,000 years ago, with the virus present in European and South American hunter-gatherers during the early Holocene. After the European Neolithic transition, Mesolithic HBV strains were replaced by a lineage likely disseminated by early farmers that prevailed throughout western Eurasia for ~4000 years, declining around the end of the 2nd millennium BCE. The only remnant of this prehistoric HBV diversity is the rare genotype G, which appears to have reemerged during the HIV pandemic.

中文翻译:

一千年的乙肝病毒进化史

乙型肝炎病毒 (HBV) 已经感染人类数千年,并且仍然是一个全球性的健康问题,但其过去的多样性和传播途径在很大程度上是未知的。我们从约 10,500 至约 400 年前的 137 名欧亚人和美洲原住民中生成了 HBV 基因组数据。我们将所有 HBV 谱系的最近共同祖先的日期定在约 20,000 到 12,000 年前,在全新世早期,该病毒存在于欧洲和南美的狩猎采集者中。在欧洲新石器时代过渡之后,中石器时代的 HBV 毒株被早期农民传播的一个谱系所取代,该谱系在整个欧亚大陆西部盛行了约 4000 年,在公元前 2 世纪末左右下降。这种史前 HBV 多样性的唯一残余是罕见的基因型 G,它似乎在 HIV 大流行期间重新出现。
更新日期:2021-10-08
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