There have been several attempts to find promising biomaterials for skin regeneration, among which polylysine (a homopolypeptide) has shown benefits in the regeneration and treatment of skin disorders. This class of biomaterials has shown exceptional abilities due to their macromolecular structure. Polylysine-based biomaterials can be used as tissue engineering scaffolds for skin regeneration, and as drug carriers or even gene delivery vectors for the treatment of skin diseases. In addition, polylysine can play a preservative role in extending the lifetime of skin tissue by minimizing the appearance of photodamaged skin. Research on polylysine is growing today, opening new scenarios that expand the potential of these biomaterials from traditional treatments to a new era of tissue regeneration. This review aims to address the basic concepts, recent trends, and prospects of polylysine-based biomaterials for skin regeneration. Undoubtedly, this class of biomaterials needs further evaluations and explorations, and many critical questions have yet to be answered.

中文翻译：

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用于皮肤再生的聚赖氨酸：最新进展回顾和未来前景


人们已经多次尝试寻找有前景的皮肤再生生物材料，其中聚赖氨酸（一种同聚肽）已在皮肤疾病的再生和治疗中显示出益处。这类生物材料由于其大分子结构而表现出非凡的能力。基于聚赖氨酸的生物材料可用作皮肤再生的组织工程支架，以及作为治疗皮肤疾病的药物载体甚至基因递送载体。此外，聚赖氨酸可以发挥防腐作用，通过最大限度地减少光损伤皮肤的出现来延长皮肤组织的寿命。如今，对聚赖氨酸的研究不断发展，开辟了新的前景，将这些生物材料的潜力从传统治疗扩展到组织再生的新时代。本综述旨在探讨用于皮肤再生的聚赖氨酸生物材料的基本概念、最新趋势和前景。毫无疑问，这类生物材料需要进一步的评估和探索，许多关键问题尚未得到解答。