An Environmentally Benign, Catalyst-Free N−C Bond Cleavage/Formation of Primary, Secondary, and Tertiary Unactivated Amides,European Journal of Organic Chemistry

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An Environmentally Benign, Catalyst-Free N−C Bond Cleavage/Formation of Primary, Secondary, and Tertiary Unactivated Amides
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2021-10-07 , DOI: 10.1002/ejoc.202101114
Vishal Kumar ₁ , Sanjeev Dhawan ₂ , Pankaj Sanjay Girase ₂ , Parvesh Singh ₃ , Rajshekhar V Karpoormath ₄

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An unprecedented methodology for the synthesis of a variety of organic amides through the coupling of wide range of unactivated primary, secondary, and tertiary diversified amides, with different amines is reported. The acid-promoted reaction is proposed to proceed through carbonyl activation and is accompanied by broad substrate scope with high tolerance for functional groups.