Chirality is one of the most important structural features in biological systems. Peptides, as a class of small biomolecules, can self-assemble into various chiral supramolecular polymers with unprecedented levels of diversity and complexity, which have practical ramifications in various fields from catalysis to sensing, optics, and biomedicine. In this review, we will focus on the chiral transfer during peptide self-assembly from the molecular scale to the nano-, micro- and mesoscale, and highlight the vital roles of chirality in determining the structures and functions of the self-assembled supramolecular polymeric materials. By rational control of the chiral self-assembly of peptide monomers, supramolecular polymers with sophisticated hierarchical structures and enhanced chemical and biological functions can readily be achieved. These can provide inspiration for researchers to design highly efficient asymmetric catalysts, templates fabricating materials with tunable chiroptics, or to synthesize biomaterials with chirality-encoded properties for biomedical applications.

手性是生物系统中最重要的结构特征之一。肽类作为一类生物小分子，可以自组装成各种手性超分子聚合物，具有前所未有的多样性和复杂性，在催化、传感、光学和生物医学等各个领域都有实际应用。在这篇综述中，我们将重点关注肽自组装过程中从分子尺度到纳米、微米和中尺度的手性转移，并强调手性在决定自组装超分子聚合物的结构和功能中的重要作用。材料。通过合理控制肽单体的手性自组装，可以很容易地实现具有复杂分级结构和增强的化学和生物功能的超分子聚合物。