In this issue of Cell Stem Cell, de Kanter et al. (2021) show that most allogeneic hematopoietic stem cells do not acquire additional somatic mutations following transplantation. However, they observe somatic mutagenesis associated with the antiviral drug ganciclovir and find plausible evidence that it may contribute to some post-transplant malignancies.

中文翻译：

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陷入抗病毒药物交火：更昔洛韦相关的 HSC 移植受者诱变

在本期Cell Stem Cell中，de Kanter 等人。(2021) 表明，大多数同种异体造血干细胞在移植后不会获得额外的体细胞突变。然而，他们观察到与抗病毒药物更昔洛韦相关的体细胞突变，并找到了可能导致某些移植后恶性肿瘤的合理证据。