Tetraphenylethylene-Featured Fluorescent Supramolecular Nanoparticles for Intracellular Trafficking of Protein Delivery and Neuroprotection,Angewandte Chemie International Edition

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Tetraphenylethylene-Featured Fluorescent Supramolecular Nanoparticles for Intracellular Trafficking of Protein Delivery and Neuroprotection
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2021-10-07 , DOI: 10.1002/anie.202111213
Ji Liu ₁ , Jinhan Sheng _{1,

2} , Leihou Shao ₁ , Qizhen Zheng ₁ , Wenting Li _{1,

2} , Xianghan Chen _{1,

2} , Lanqun Mao ₃ , Ming Wang _{1,

2}

Affiliation

The hierarchical self-assembly of tetraphenylethylene (TPE)-featured M₂L₄-type metal–organic cages (MOCs) and β-cyclodextrin-conjugated polyethylenimine (PEI-βCD) via host–guest chemistry generates fluorescent supramolecular nanoparticles (FSNPs) that can deliver protein into neural cells, a cell line that is hard to transfect by the conventional strategy.

中文翻译：

四苯基乙烯特征的荧光超分子纳米颗粒用于蛋白质递送和神经保护的细胞内运输

四苯基乙烯(TPE) 特征的 M ₂ L ₄型金属有机笼 (MOC) 和 β-环糊精共轭聚乙烯亚胺 (PEI-βCD) 通过主客体化学分层自组装产生荧光超分子纳米粒子 (FSNP)可以将蛋白质输送到神经细胞中，这是一种传统策略难以转染的细胞系。

更新日期：2021-12-06

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