Most drugs or the natural substances reputed to display some biological activity are hydrophobic molecules that demonstrate low bioavailability regardless of their mode of absorption. Resveratrol and its derivatives belong to the chemical group of stilbenes; while stilbenes are known to possess very interesting properties, these are limited by their poor aqueous solubility as well as low bioavailability in animals and humans. Among the substances capable of forming nanomolecular inclusion complexes which can be used for drug delivery, cyclodextrins show spectacular physicochemical and biomedical implications in stilbene chemistry for their possible application in nanomedicine. By virtue of their properties, cyclodextrins have also demonstrated their possible use in green chemistry for the synthesis of stilbene glucosylated derivatives with potential applications in dermatology and cosmetics. Compared to chemical synthesis and genetically modified microorganisms, plant cell or tissue systems provide excellent models for obtaining stilbenes in few g/L quantities, making feasible the production of these compounds at a large scale. However, the biosynthesis of stilbenes is only possible in the presence of the so-called elicitor compounds, the most commonly used of which are cyclodextrins. We also report here on the induction of resveratrol production by cyclodextrins or combinatory elicitation with methyljasmonate in plant cell systems as well as the mechanisms by which they are able to trigger a stilbene response. The present article therefore discusses the role of cyclodextrins in stilbene chemistry both at the physico-chemical level as well as the biomedical and biotechnological levels, emphasizing the notion of "easy alliance" between these compounds and stilbenes.

大多数被认为具有某些生物活性的药物或天然物质是疏水性分子，无论其吸收方式如何，其生物利​​用度都较低。白藜芦醇及其衍生物属于二苯乙烯的化学组；虽然众所周知，二苯乙烯具有非常有趣的特性，但它们的水溶性差以及在动物和人类中的生物利用度低，这限制了这些特性。在能够形成可用于药物递送的纳米分子包合物的物质中，环糊精在二苯乙烯化学中显示出惊人的物理化学和生物医学意义，因为它们可能在纳米医学中应用。凭借它们的特性，环糊精还证明了它们在绿色化学中的可能用途，用于合成二苯乙烯葡萄糖基化衍生物，在皮肤病学和化妆品中具有潜在应用。与化学合成和转基因微生物相比，植物细胞或组织系统提供了极好的模型来获得少量 g/L 的二苯乙烯，使大规模生产这些化合物成为可能。然而，二苯乙烯的生物合成只有在所谓的诱导剂化合物存在下才有可能，其中最常用的是环糊精。我们还在此报告了在植物细胞系统中环糊精诱导白藜芦醇产生或与茉莉酮酸甲酯联合诱导，以及它们能够触发二苯乙烯反应的机制。