Influence of Legacy Mercury on Antibiotic Resistomes: Evidence from Agricultural Soils with Different Cropping Systems,Environmental Science & Technology

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Influence of Legacy Mercury on Antibiotic Resistomes: Evidence from Agricultural Soils with Different Cropping Systems
Environmental Science & Technology ( IF 10.8 ) Pub Date : 2021-10-06 , DOI: 10.1021/acs.est.1c04030
Yi Zhao ₁ , Hang-Wei Hu ₂ , Jian-Qiang Su ₃ , Xiuli Hao _{4,

5} , Huaming Guo ₁ , Yu-Rong Liu _{4,

5} , Yong-Guan Zhu _{3,

6}

Affiliation

Agricultural soils are important reservoirs for antibiotic resistance genes (ARGs), which have close linkage to human health via crop production. Metal stress in environments may function as a selection pressure for antibiotic resistomes. However, there is still a lack of field studies focusing on the effect of historical mercury (Hg) contamination on antibiotic resistomes in agricultural soils. Here, we explored the ARG profile in soils with different cropping systems (paddy and upland) and linked them to legacy Hg exposure. We found that ARG profiles were significantly different between paddy and upland soils. However, both paddy and upland soils with long-term field Hg contamination harbored higher diversity and abundance of ARGs than non-polluted soils. The co-occurrence network reveals significant associations among Hg, Hg resistance genes, mobile genetic elements (MGEs), and ARGs. Together with path analysis showing legacy Hg possibly affecting soil resistomes through the shifts of soil microbiota, Hg resistance genes, and MGEs, we suggest that legacy Hg-induced potential co-selection might elevate the ARG level. Redundancy analysis further supports that legacy Hg pollution had a significant association with ARG variations in the paddy and upland soils (P < 0.01). Collectively, our results highlight the underappreciated role of legacy Hg as a potential persistent selecting agent in contributing to soil ARGs in agroecosystems.

中文翻译：

遗留汞对抗生素抗性的影响：来自不同种植系统农业土壤的证据

农业土壤是抗生素抗性基因 (ARG) 的重要储存库，其通过作物生产与人类健康密切相关。环境中的金属应力可能会作为抗生素抗性组的选择压力。然而，仍然缺乏关注历史汞 (Hg) 污染对农业土壤中抗生素抗性组的影响的实地研究。在这里，我们探索了具有不同种植系统（稻谷和高地）的土壤中的 ARG 分布，并将它们与遗留的汞暴露联系起来。我们发现水稻和旱地土壤的 ARG 剖面显着不同。然而，与未受污染的土壤相比，长期受到田间汞污染的水稻和旱地土壤具有更高的 ARG 多样性和丰度。共现网络揭示了 Hg、Hg 抗性基因、移动遗传元件 (MGE) 和 ARG。结合路径分析显示遗留 Hg 可能通过土壤微生物群、Hg 抗性基因和 MGE 的变化影响土壤抗性组，我们认为遗留 Hg 诱导的潜在共选择可能会提高 ARG 水平。冗余分析进一步支持遗留 Hg 污染与水稻和旱地土壤的 ARG 变化显着相关。P < 0.01)。总的来说，我们的结果强调了遗留汞作为一种潜在的持久性选择剂在农业生态系统中促进土壤 ARGs 的作用未被充分认识。

更新日期：2021-10-19

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