Chromatic Pupillometry in Isolated Rapid Eye Movement Sleep Behavior Disorder,Movement Disorders

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Chromatic Pupillometry in Isolated Rapid Eye Movement Sleep Behavior Disorder
Movement Disorders ( IF 7.4 ) Pub Date : 2021-10-07 , DOI: 10.1002/mds.28809
Chiara La Morgia ₁ , Martina Romagnoli ₁ , Fabio Pizza _{1,

2} , Francesco Biscarini ₂ , Marco Filardi _{2,

3,

4} , Vincenzo Donadio ₁ , Michele Carbonelli ₂ , Giulia Amore ₂ , Jason C Park ₅ , Michele Tinazzi ₆ , Valerio Carelli _{1,

2} , Rocco Liguori _{1,

2} , Giuseppe Plazzi _{1,

7} , Elena Antelmi ₆

Affiliation

Melanopsin retinal ganglion cell (mRGC)-mediated pupillary light reflex (PLR) abnormalities have been documented in several neurodegenerative disorders including Parkinson's disease. Overall, isolated rapid eye movement (REM) sleep behavior disorder (iRBD) represents the strongest prodromal risk factor for impending α-synucleinopathies.

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