Metabolic regulation plays important roles in embryo development and uterine receptivity during early pregnancy, ultimately influencing pregnancy efficiency in mammals. The important roles of lipid metabolism during early pregnancy have not been fully understood. Here, we described the regulatory roles of phospholipid, sphingolipid, and cholesterol metabolism on early embryo development, implantation, and uterine receptivity through production of cannabinoids, prostaglandins, lysophosphatidic acid, sphingosine-1-phosphate, and steroid hormones. Moreover, the impacts of lipids and fatty acids on embryo development potential and the related epigenetic modifications are also discussed. This review aims to elucidate the modulations of lipid metabolism on uterine receptivity and embryo development, contributing to novel strategies to establish dietary balanced lipids and fatty acids for reducing early embryo loss.

代谢调节在妊娠早期的胚胎发育和子宫容受性中起重要作用，最终影响哺乳动物的妊娠效率。妊娠早期脂质代谢的重要作用尚未完全清楚。在这里，我们描述了磷脂、鞘脂和胆固醇代谢通过产生大麻素、前列腺素、溶血磷脂酸、1-磷酸鞘氨醇和类固醇激素对早期胚胎发育、植入和子宫容受性的调节作用。此外，还讨论了脂质和脂肪酸对胚胎发育潜力的影响以及相关的表观遗传修饰。本综述旨在阐明脂质代谢对子宫容受性和胚胎发育的调节作用，