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Targetable Conformationally Restricted Cyanines Enable Photon-Count-Limited Applications**
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2021-10-04 , DOI: 10.1002/anie.202109749 Patrick Eiring 1 , Ryan McLaughlin 2 , Siddharth S Matikonda 2 , Zhongying Han 3 , Lennart Grabenhorst 4 , Dominic A Helmerich 1 , Mara Meub 1 , Gerti Beliu 1 , Michael Luciano 2 , Venu Bandi 2 , Niels Zijlstra 3 , Zhen-Dan Shi 5 , Sergey G Tarasov 6 , Rolf Swenson 5 , Philip Tinnefeld 4 , Viktorija Glembockyte 4 , Thorben Cordes 3 , Markus Sauer 1 , Martin J Schnermann 2
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2021-10-04 , DOI: 10.1002/anie.202109749 Patrick Eiring 1 , Ryan McLaughlin 2 , Siddharth S Matikonda 2 , Zhongying Han 3 , Lennart Grabenhorst 4 , Dominic A Helmerich 1 , Mara Meub 1 , Gerti Beliu 1 , Michael Luciano 2 , Venu Bandi 2 , Niels Zijlstra 3 , Zhen-Dan Shi 5 , Sergey G Tarasov 6 , Rolf Swenson 5 , Philip Tinnefeld 4 , Viktorija Glembockyte 4 , Thorben Cordes 3 , Markus Sauer 1 , Martin J Schnermann 2
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Modern fluorescence-based methods put intense demands on probe molecules. Here we report conformationally restrained cyanines suitable for biomolecule labeling. These efforts establish contexts in which reduced cyanine isomerization leads to a significant enhance in photon output.
中文翻译：
可靶向构象限制的花青可实现光子计数有限的应用**
现代基于荧光的方法对探针分子提出了很高的要求。在这里，我们报告了适合生物分子标记的构象限制花青。这些努力建立了减少花青异构化导致光子输出显着增强的背景。
更新日期：2021-12-06
中文翻译：
可靶向构象限制的花青可实现光子计数有限的应用**
现代基于荧光的方法对探针分子提出了很高的要求。在这里，我们报告了适合生物分子标记的构象限制花青。这些努力建立了减少花青异构化导致光子输出显着增强的背景。
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