Edible ligand-metal-organic frameworks (EL-MOFs) have a tremendous potential in practical applications including but not limiting to biomedicine, chemistry, environment, food, and pharmacy. EL-MOFs not only retain advantages of conventional MOFs with high porosity, large specific surface area, flexible pore structure, and abundant binding sites, but also bring desirable appeals like nontoxicity, biocompatibility, and environmental friendliness. Here, the synthesis and structures of EL-MOFs were firstly introduced. Secondly, their physical and chemical properties including thermal stability, chemical stability, and adsorption and desorption were objectively evaluated. Thirdly, biocompatibility and potential applications of EL-MOFs, especially reported in the last five years, were comprehensively summarized and discussed. At last, potential opportunities and challenges of EL-MOFs were prospected.

可食用配体-金属-有机骨架（EL-MOFs）在实际应用中具有巨大的潜力，包括但不限于生物医学、化学、环境、食品和制药。EL-MOFs不仅保留了传统MOFs的高孔隙率、大比表面积、灵活的孔结构和丰富的结合位点等优点，而且还带来了无毒、生物相容性和环境友好等理想的吸引力。在这里，首先介绍了EL-MOFs的合成和结构。其次，客观地评价了它们的物理化学性质，包括热稳定性、化学稳定性、吸附和解吸。第三，全面总结和讨论了EL-MOFs的生物相容性和潜在应用，特别是最近五年的报道。最后，