The mouse cortico–basal ganglia–thalamic network,Nature

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The mouse cortico–basal ganglia–thalamic network
Nature ( IF 50.5 ) Pub Date : 2021-10-06 , DOI: 10.1038/s41586-021-03993-3
Nicholas N Foster _{1,

2} , Joshua Barry ₃ , Laura Korobkova ₂ , Luis Garcia _{1,

2} , Lei Gao _{1,

2} , Marlene Becerra ₂ , Yasmine Sherafat ₂ , Bo Peng ₄ , Xiangning Li _{5,

6} , Jun-Hyeok Choi ₇ , Lin Gou _{1,

2} , Brian Zingg _{1,

2} , Sana Azam ₂ , Darrick Lo _{1,

2} , Neda Khanjani ₂ , Bin Zhang _{1,

2} , Jim Stanis ₂ , Ian Bowman _{1,

2} , Kaelan Cotter ₂ , Chunru Cao _{1,

2} , Seita Yamashita _{1,

2} , Amanda Tugangui _{1,

2} , Anan Li _{5,

6,

8} , Tao Jiang ₆ , Xueyan Jia ₆ , Zhao Feng ₆ , Sarvia Aquino ₂ , Hyun-Seung Mun _{1,

2} , Muye Zhu _{1,

2} , Anthony Santarelli ₂ , Nora L Benavidez _{1,

2} , Monica Song _{1,

2} , Gordon Dan ₂ , Marina Fayzullina _{1,

2} , Sarah Ustrell ₂ , Tyler Boesen _{1,

2} , David L Johnson ₂ , Hanpeng Xu _{1,

2} , Michael S Bienkowski ₂ , X William Yang _{3,

9} , Hui Gong _{5,

6,

8} , Michael S Levine ₃ , Ian Wickersham ₁₀ , Qingming Luo _{5,

6,

11} , Joel D Hahn ₁₂ , Byung Kook Lim ₇ , Li I Zhang ₄ , Carlos Cepeda ₃ , Houri Hintiryan _{1,

2} , Hong-Wei Dong _{1,

2}

Affiliation

UCLA Brain Research and Artificial Intelligence Nexus, Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Jane and Terry Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, MoE Key Laboratory for Biomedical Photonics, School of Engineering Sciences, Huazhong University of Science and Technology, Wuhan, China.
HUST-Suzhou Institute for Brainsmatics, JITRI Institute for Brainsmatics, Suzhou, China.
Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Science, Shanghai, China.
Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience, Los Angeles, CA, USA.
McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
School of Biomedical Engineering, Hainan University, Haikou, China.
Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.

The cortico–basal ganglia–thalamo–cortical loop is one of the fundamental network motifs in the brain. Revealing its structural and functional organization is critical to understanding cognition, sensorimotor behaviour, and the natural history of many neurological and neuropsychiatric disorders. Classically, this network is conceptualized to contain three information channels: motor, limbic and associative^1,2,3,4. Yet this three-channel view cannot explain the myriad functions of the basal ganglia. We previously subdivided the dorsal striatum into 29 functional domains on the basis of the topography of inputs from the entire cortex⁵. Here we map the multi-synaptic output pathways of these striatal domains through the globus pallidus external part (GPe), substantia nigra reticular part (SNr), thalamic nuclei and cortex. Accordingly, we identify 14 SNr and 36 GPe domains and a direct cortico-SNr projection. The striatonigral direct pathway displays a greater convergence of striatal inputs than the more parallel striatopallidal indirect pathway, although direct and indirect pathways originating from the same striatal domain ultimately converge onto the same postsynaptic SNr neurons. Following the SNr outputs, we delineate six domains in the parafascicular and ventromedial thalamic nuclei. Subsequently, we identify six parallel cortico–basal ganglia–thalamic subnetworks that sequentially transduce specific subsets of cortical information through every elemental node of the cortico–basal ganglia–thalamic loop. Thalamic domains relay this output back to the originating corticostriatal neurons of each subnetwork in a bona fide closed loop.

中文翻译：

小鼠皮质-基底神经节-丘脑网络

皮质-基底神经节-丘脑-皮质环是大脑中的基本网络基序之一。揭示其结构和功能组织对于理解认知、感觉运动行为以及许多神经和神经精神疾病的自然史至关重要。传统上，该网络被概念化为包含三个信息通道：运动、边缘和联想^1,2,3,4。然而，这种三通道观点无法解释基底神经节的无数功能。^{我们之前根据整个皮层5}输入的地形图将背侧纹状体细分为 29 个功能域. 在这里，我们通过苍白球外部 (GPe)、黑质网状部分 (SNr)、丘脑核和皮层绘制这些纹状体区域的多突触输出通路。因此，我们确定了 14 个 SNr 和 36 个 GPe 域以及一个直接的皮质-SNr 投影。与更平行的纹状体间接通路相比，纹状体黑质直接通路显示出更多的纹状体输入收敛，尽管源自相同纹状体域的直接和间接通路最终会聚到相同的突触后 SNr 神经元上。根据 SNr 输出，我们描绘了束旁和腹内侧丘脑核的六个区域。随后，我们确定了六个平行的皮质-基底神经节-丘脑子网络，它们通过皮质-基底神经节-丘脑环路的每个基本节点依次转换特定的皮质信息子集。丘脑域将此输出中继回真实闭环中每个子网络的原始皮质纹状体神经元。

更新日期：2021-10-06

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