Parkinson's disease (PD) is a highly age-related disorder, where common genetic risk variants affect both disease risk and age at onset. A statistical approach that integrates these effects across all common variants may be clinically useful for individual risk stratification. A polygenic hazard score methodology, leveraging a time-to-event framework, has recently been successfully applied in other age-related disorders.

中文翻译：

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通过多基因危险评分对年龄依赖性帕金森病风险进行遗传分层

帕金森病 (PD) 是一种与年龄高度相关的疾病，其中常见的遗传风险变异会影响疾病风险和发病年龄。将这些影响整合到所有常见变异中的统计方法可能在临床上对个体风险分层有用。利用事件发生时间框架的多基因危害评分方法最近已成功应用于其他与年龄相关的疾病。