Glia Imaging Differentiates Multiple System Atrophy from Parkinson's Disease: A Positron Emission Tomography Study with [11C]PBR28 and Machine Learning Analysis,Movement Disorders

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Glia Imaging Differentiates Multiple System Atrophy from Parkinson's Disease: A Positron Emission Tomography Study with [11C]PBR28 and Machine Learning Analysis
Movement Disorders ( IF 7.4 ) Pub Date : 2021-10-05 , DOI: 10.1002/mds.28814
Aurelija Jucaite _{1,

2} , Zsolt Cselényi _{1,

2} , William C. Kreisl ₃ , Eugenii A. Rabiner _{4,

5} , Andrea Varrone ₂ , Richard E. Carson ₆ , Juha O. Rinne ₇ , Alicia Savage ₈ , Magnus Schou _{1,

2} , Peter Johnström _{1,

2} , Per Svenningsson ₉ , Olivier Rascol ₁₀ , Wassilios G. Meissner _{11,

12,

13} , Paolo Barone ₁₄ , Klaus Seppi ₁₅ , Horacio Kaufmann ₁₆ , Gregor K. Wenning ₁₇ , Werner Poewe ₁₇ , Lars Farde ₂

Affiliation

PET Science Centre, Personalized Medicine and Biosamples R&D, AstraZeneca Stockholm Sweden
Department of Clinical Neuroscience Centre for Psychiatry Research, Karolinska Institutet Stockholm Sweden
Taub Institute, Department of Neurology Columbia University Irving Medical Centre New York New York USA
Invicro London UK
Centre for Neuroimaging Sciences Institute of Psychiatry, Psychology and Neuroscience, King's College London London UK
Yale University PET Centre New Haven Connecticut USA
Turku PET Centre University of Turku and Turku University Hospital Turku Finland
R&D, AstraZeneca Waltham Massachusetts USA
Section of Neurology, Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden
French MSA Reference Centre, Clinical Investigation Centre CIC1436, Department of Neurosciences and Clinical Pharmacology, NeuroToul COEN Centre UMR 1 214‐ToNIC and University Hospital of Toulouse, INSERM and University of Toulouse 3 Toulouse France
CRMR AMS, Service de Neurologie‐Maladies Neurodégénératives CHU Bordeaux Bordeaux France
University Bordeaux, CNRS, IMN, UMR 5293 Bordeaux France
Department of Medicine University of Otago, Christchurch, New Zealand Brain Research Institute Christchurch New Zealand
Neurodegenerative Disease Centre University of Salerno Salerno Italy
Department of Neurology Innsbruck Medical University Innsbruck Austria
Department of Medicine NYU Grossman School of Medicine New York New York USA
Division of Clinical Neurobiology, Department of Neurology Innsbruck Medical University Innsbruck Austria

The clinical diagnosis of multiple system atrophy (MSA) is challenged by overlapping features with Parkinson's disease (PD) and late-onset ataxias. Additional biomarkers are needed to confirm MSA and to advance the understanding of pathophysiology. Positron emission tomography (PET) imaging of the translocator protein (TSPO), expressed by glia cells, has shown elevations in MSA.

中文翻译：

神经胶质成像区分多系统萎缩和帕金森病：使用 [11C]PBR28 和机器学习分析的正电子发射断层扫描研究

多系统萎缩 (MSA) 的临床诊断受到与帕金森病 (PD) 和迟发性共济失调的重叠特征的挑战。需要额外的生物标志物来确认 MSA 并促进对病理生理学的理解。由胶质细胞表达的易位蛋白 (TSPO) 的正电子发射断层扫描 (PET) 成像显示 MSA 升高。

更新日期：2021-10-05

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