当前位置: X-MOL 学术Chest › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Oral Positive Expiratory Pressure Device for Excessive Dynamic Airway Collapse Caused by Emphysema
Chest ( IF 9.5 ) Pub Date : 2021-10-05 , DOI: 10.1016/j.chest.2021.04.059
Muhammad Ahsan Zafar 1 , Ruchira Sengupta 1 , Alister Bates 2 , Jason C Woods 2 , Christopher Radchenko 1 , Francis X McCormack 1 , Ralph J Panos 3
Affiliation  

Excessive dynamic airway collapse (EDAC) contributes to breathlessness and reduced quality of life in individuals with emphysema. We tested a novel, portable, oral positive expiratory pressure (o-PEP) device in a patient with emphysema and EDAC. MRI revealed expiratory tracheal narrowing to 80 mm2 that increased to 170 mm2 with the o-PEP device. After 2-weeks use of the o-PEP device for 33% to 66% of activities, breathlessness, quality of life, and exertional dyspnea improved compared with minimal clinically important differences (MCID): University of California-San Diego Shortness of Breath questionnaire score declined 69 to 42 (MCID, ≥5), St. George’s Respiratory Questionnaire score decreased 71 to 27 (MCID, ≥4), and before and after the 6-minute walk test Borg score difference improved from Δ3 to Δ2 (MCID, ≥1). During the 6-minute walk test on room air without the use of the o-PEP device, oxyhemoglobin saturation declined 91% to 83%; whereas, with the o-PEP device, the nadir was 90%. Use of the o-PEP device reduced expiratory central airway collapse and improved dyspnea, quality of life, and exertional desaturation in a patient with EDAC and emphysema.



中文翻译:

经口呼气正压装置治疗肺气肿引起的过度动态气道塌陷

过度动态气道塌陷 (EDAC) 会导致肺气肿患者出现呼吸困难和生活质量下降。我们在一名患有肺气肿和 EDAC 的患者身上测试了一种新型的便携式口服呼气正压 (o-PEP) 装置。MRI 显示呼气气管狭窄至 80 mm 2,然后增加到 170 mm 2使用 o-PEP 设备。使用 o-PEP 设备进行 33% 至 66% 的活动 2 周后,与最小临床重要差异 (MCID) 相比,呼吸困难、生活质量和劳力性呼吸困难得到改善:加州大学圣地亚哥分校呼吸急促问卷评分从 69 分下降到 42 分(MCID,≥5),圣乔治呼吸问卷评分从 71 分下降到 27 分(MCID,≥4),并且在 6 分钟步行测试前后 Borg 评分差异从 Δ3 提高到 Δ2(MCID, ≥1)。在不使用 o-PEP 装置的室内空气中进行 6 分钟步行测试期间,氧合血红蛋白饱和度下降了 91% 至 83%;而使用 o-PEP 设备时,最低点为 90%。o-PEP 装置的使用减少了 EDAC 和肺气肿患者的呼气中央气道塌陷并改善了呼吸困难、生活质量和劳力性去饱和。

更新日期:2021-10-06
down
wechat
bug