Electrochemical detection of metabolites is essential for early diagnosis and continuous monitoring of a variety of health conditions. This review focuses on organic electronic material-based metabolite sensors and highlights their potential to tackle critical challenges associated with metabolite detection. We provide an overview of the distinct classes of organic electronic materials and biorecognition units used in metabolite sensors, explain the different detection strategies developed to date, and identify the advantages and drawbacks of each technology. We then benchmark state-of-the-art organic electronic metabolite sensors by categorizing them based on their application area (in vitro, body-interfaced, in vivo, and cell-interfaced). Finally, we share our perspective on using organic bioelectronic materials for metabolite sensing and address the current challenges for the devices and progress to come.

中文翻译：

---

用于代谢物传感的有机生物电子器件

代谢物的电化学检测对于早期诊断和持续监测各种健康状况至关重要。本综述重点关注基于有机电子材料的代谢物传感器，并强调它们在应对与代谢物检测相关的关键挑战方面的潜力。我们概述了代谢物传感器中使用的不同类别的有机电子材料和生物识别单元，解释了迄今为止开发的不同检测策略，并确定了每种技术的优缺点。然后，我们根据其应用领域（体外、身体接口、体内）对最先进的有机电子代谢物传感器进行分类，从而对它们进行基准测试和单元接口）。最后，我们分享了我们对使用有机生物电子材料进行代谢物传感的看法，并解决了设备当前面临的挑战和未来的进展。