Background/aims To understand whether the epidemiology, aetiologies, common pathogens and the antibiotic efficacy against the identified bacteria of periorbital cellulitis in adults have changed recently (2010–2019) compared with the past decade (2000–2009). Methods Adult patients (n=224) diagnosed with preseptal cellulitis and orbital cellulitis admitted to Kaohsiung Veterans General Hospital during 2000–2019 were retrospectively reviewed. Demographic and clinical characteristics, isolated pathogens and antibiotic susceptibility tests against the commonly cultured bacteria were analysed. Results Preseptal cellulitis showed a tendency of female predominance. Patients in their 60s showed an incidence peak; more cases were observed during winter. The most common predisposing factor was dacryocystitis (15.5%–30.5%), followed by hordeolum (15.5%–24.8%). Aetiology of sinusitis (p=0.001) decreased and that of conjunctivitis (p=0.007) increased significantly with time. Culture results of nasopharyngeal swabs and local abscess showed higher positivity rate than conjunctival swab. The most common isolates were methicillin-susceptible Staphylococcus aureus , methicillin-resistant S. aureus , coagulase-negative staphylococci and Pseudomonas aeruginosa . Antibiotics including fluoroquinolones and vancomycin were effective; in contrast, ampicillin/sulbactam and oxacillin showed decreasing efficacy against gram-positive bacteria. For antibiotic treatment against P. aeruginosa , fluoroquinolones, ceftazidime, piperacillin and imipenem were ideal choices. Conclusion In isolated pathogens, the increasing trend of methicillin-resistant S. aureus detection was compatible with reducing oxacillin efficacy against periorbital infection. In our study, the report of antibiotic efficacy against the most common identified bacteria offered empirical choices for hospitalised patients with periorbital infection before obtaining culture results. All data relevant to the study are included in the article or uploaded as supplemental information. All data relevant to the study are included in the article or uploaded as supplementary information.

中文翻译：

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2000-2009 年和 2010-2019 年成年隔前蜂窝织炎和眼眶蜂窝织炎患者的特征、病因、分离的病原体和抗生素疗效的差异

背景/目的 了解与过去十年（2000-2009 年）相比，最近（2010-2019 年）成人眶周蜂窝织炎的流行病学、病原学、常见病原体和抗生素对已鉴定细菌的疗效是否发生了变化。方法 回顾性分析 2000 年至 2019 年间高雄荣民总医院诊断为隔前蜂窝织炎和眼眶蜂窝织炎的成年患者 (n=224)。分析了人口统计学和临床​​特征、分离的病原体和针对常见培养细菌的抗生素敏感性试验。结果房间隔前蜂窝织炎呈女性多发趋势。60多岁的患者呈发病高峰；冬季观察到更多病例。最常见的诱发因素是泪囊炎 (15.5%–30.5%)，其次是麦粒肿 (15.5%–24. 8%）。随着时间的推移，鼻窦炎的病因 (p=0.001) 减少，结膜炎的病因 (p=0.007) 显着增加。鼻咽拭子和局部脓肿培养结果阳性率高于结膜拭子。最常见的分离株是甲氧西林敏感金黄色葡萄球菌、甲氧西林耐药金黄色葡萄球菌、凝固酶阴性葡萄球菌和铜绿假单胞菌。包括氟喹诺酮类和万古霉素在内的抗生素有效；相比之下，氨苄西林/舒巴坦和苯唑西林对革兰氏阳性菌的疗效下降。对于针对铜绿假单胞菌的抗生素治疗，氟喹诺酮类、头孢他啶、哌拉西林和亚胺培南是理想的选择。结论 在分离的病原体中，耐甲氧西林金黄色葡萄球菌呈上升趋势。金黄色葡萄球菌检测与降低苯唑西林对眶周感染的疗效相一致。在我们的研究中，抗生素对最常见细菌的疗效报告为眼周感染住院患者在获得培养结果前提供了经验选择。与研究相关的所有数据都包含在文章中或作为补充信息上传。所有与研究相关的数据都包含在文章中或作为补充信息上传。