Six-year incidence of age-related macular degeneration and correlation to OCT-derived drusen volume measurements in a Chinese population,British Journal of Ophthalmology

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Six-year incidence of age-related macular degeneration and correlation to OCT-derived drusen volume measurements in a Chinese population
British Journal of Ophthalmology ( IF 3.7 ) Pub Date : 2023-03-01 , DOI: 10.1136/bjophthalmol-2021-319290
Anna CS Tan _{1,

2,

3} , Miao Li Chee ₃ , Beau J Fenner _{1,

2,

3} , Paul Mitchell ₄ , Yih Chung Tham _{1,

2,

3} , Tyler Rim _{1,

2,

3} , Kelvin Teo _{1,

2,

3,

5} , Shaun S Sim _{1,

2,

3} , Ching Yu Cheng _{1,

2,

3} , Tien Yin Wong _{1,

2,

3} , Usha Chakravarthy ₆ , Chui Ming Gemmy Cheung _{1,

2,

3}

Affiliation

Aims To report the 6-year incidence of optical coherence tomography (OCT)-derived age-related changes in drusen volume and related systemic and ocular associations. Methods Chinese adults aged 40 years and older were assessed at baseline and 6 years with colour fundus photography (CFP) and spectral domain (SD) OCT. CFPs were graded for age-related macular degeneration (AMD) features and drusen volume was generated using commercially available automated software. Results A total of 4172 eyes of 2580 participants (mean age 58.12±9.03 years; 51.12% women) had baseline and 6-year follow-up CFP for grading, of these, 2130 eyes of 1305 participants had gradable SD-OCT images, available for analysis. Based on CFP grading, 136 (3.39%) participants developed incident early AMD and 10 (0.25%) late AMD. Concurrently, retinal pigment epithelial-Bruch’s membrane (RPE-BrC) volumes decreased, remained stable and increased in 6.8%, 78.5% and 14.7%, respectively, over 6 years. In eyes where RPE-BrC volumes were >0 mm3 at baseline, this was associated with two-fold higher prevalence rate of any AMD at baseline (p<0.001). Multivariable analysis showed that when compared with eyes where RPE-BrC volume was unchanged, volume decrease was significantly associated with older age (OR=1.30; p<0.001), smoking (OR=2.21; p=0.001) and chronic kidney disease (OR=3.4, p=0.008), while increase was associated with older age (OR=1.36; p<0.001) and hypertension (OR=1.43; p=0.016). Conclusion AMD incidence detected at 6 years on CFP and correlated OCT-derived drusen volume measurement change is low. Older age and some systemic risk factors are associated with drusen volume change, and our data provide new insights into relationship between systemic risk factors and outer retinal morphology in Asian eyes. All data relevant to the study are included in the article or uploaded as supplementary information. Data is de-identified participant data available from out database not reusable without permission.

更新日期：2023-02-20

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