Cancer cachexia is characterized by a negative energy balance, muscle and adipose tissue wasting, insulin resistance, and systemic inflammation. Because of its strong negative impact on prognosis and its multifactorial nature that is still not fully understood, cachexia remains an important challenge in the field of cancer treatment. Recent animal studies indicate that the gut microbiota is involved in the pathogenesis and manifestation of cancer cachexia, but human data are lacking. The present study investigates gut microbiota composition, short-chain fatty acids (SCFA), and inflammatory parameters in human cancer cachexia.

中文翻译：

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恶病质癌症患者的肠道微生物群和短链脂肪酸改变

癌症恶病质的特征是能量负平衡、肌肉和脂肪组织萎缩、胰岛素抵抗和全身炎症。由于其对预后的强烈负面影响及其多因素性质仍未完全了解，恶病质仍然是癌症治疗领域的重要挑战。最近的动物研究表明，肠道微生物群参与癌症恶病质的发病机制和表现，但缺乏人类数据。本研究调查了人类癌症恶病质中的肠道微生物群组成、短链脂肪酸 (SCFA) 和炎症参数。