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The Path to Controlled Delivery of Reactive Sulfur Species
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2021-10-04 , DOI: 10.1021/acs.accounts.1c00506
Xiang Ni 1 , Shane S Kelly 2 , Shi Xu 1 , Ming Xian 1
Affiliation  

Reactive sulfur species (RSS) play regulatory roles in many physiological and pathological processes. Since the discovery of hydrogen sulfide (H2S) as a nitric oxide (NO)-like signaling molecule, understanding the chemical biology of H2S and H2S-related RSS, such as hydropersulfides (RSSH) and polysulfides (H2Sn), has become a fast-growing research field. However, the research on these RSS has technical difficulties due to their high reactivity and instability. To solve this problem, considerable efforts have been put into the development of unique RSS releasing compounds (e.g., donors) or in situ RSS generation systems. This Account tells the story of our research group’s effort to develop novel RSS donors.

中文翻译:

活性硫物质受控传递的途径

活性硫物质 (RSS) 在许多生理和病理过程中发挥调节作用。自从发现硫化氢 (H 2 S) 作为一氧化氮 (NO) 样信号分子后,了解 H 2 S 和 H 2 S 相关 RSS的化学生物学,例如氢过硫化物 (RSSH) 和多硫化物 (H 2 S n ),已成为一个快速发展的研究领域。然而,这些RSS的研究由于它们的高反应性和不稳定性而存在技术困难。为了解决这个问题,已经投入了大量的努力来开发独特的 RSS 释放化合物(例如,供体)或原位RSS 生成系统。这个帐户讲述了我们的研究小组努力开发新型 RSS 捐助者的故事。
更新日期:2021-10-19
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