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The Immune Response in Multiple Sclerosis
Annual Review of Pathology: Mechanisms of Disease ( IF 28.4 ) Pub Date : 2022-01-24 , DOI: 10.1146/annurev-pathol-052920-040318
Sofía Rodríguez Murúa 1 , Mauricio F Farez 1 , Francisco J Quintana 2
Affiliation  

Multiple sclerosis (MS) is a chronic autoimmune, inflammatory, and neurodegenerative disease that affects the central nervous system (CNS). MS is characterized by immune dysregulation, which results in the infiltration of the CNS by immune cells, triggering demyelination, axonal damage, and neurodegeneration. Although the exact causes of MS are not fully understood, genetic and environmental factors are thought to control MS onset and progression. In this article, we review the main immunological mechanisms involved in MS pathogenesis.

中文翻译:


多发性硬化症的免疫反应

多发性硬化症 (MS) 是一种影响中枢神经系统 (CNS) 的慢性自身免疫性、炎症性和神经退行性疾病。MS的特点是免疫失调,导致免疫细胞浸润中枢神经系统,引发脱髓鞘、轴突损伤和神经变性。尽管尚未完全了解 MS 的确切原因,但遗传和环境因素被认为控制着 MS 的发病和进展。在本文中,我们回顾了 MS 发病机制中涉及的主要免疫机制。

更新日期:2022-01-25
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