A Mycobacterium tuberculosis NBTI DNA gyrase inhibitor is active against Mycobacterium abscessus,Antimicrobial Agents and Chemotherapy

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A Mycobacterium tuberculosis NBTI DNA gyrase inhibitor is active against Mycobacterium abscessus
Antimicrobial Agents and Chemotherapy ( IF 4.9 ) Pub Date : 2021-10-04 , DOI: 10.1128/aac.01514-21
Uday S Ganapathy ₁ , Rubén González Del Río ₂ , Mónica Cacho-Izquierdo ₂ , Fátima Ortega ₂ , Joël Lelièvre ₂ , David Barros-Aguirre ₂ , Wassihun Wedajo Aragaw ₁ , Matthew D Zimmerman ₁ , Marissa Lindman ₁ , Véronique Dartois _{1,

3} , Martin Gengenbacher _{1,

3} , Thomas Dick _{1,

3,

4}

Affiliation

Fluoroquinolones – the only clinically used DNA gyrase inhibitors – are effective against tuberculosis (TB) but are in limited clinical use for non-tuberculous mycobacteria (NTM) lung infections due to intrinsic drug resistance. We sought to test ...

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