Efficacy of Nano-Encapsulated Daptomycin in an Experimental Methicillin-Resistant Staphylococcus aureus (MRSA) Bone and Joint Infection Model,Antimicrobial Agents and Chemotherapy

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Efficacy of Nano-Encapsulated Daptomycin in an Experimental Methicillin-Resistant Staphylococcus aureus (MRSA) Bone and Joint Infection Model
Antimicrobial Agents and Chemotherapy ( IF 4.1 ) Pub Date : 2021-10-04 , DOI: 10.1128/aac.00768-21
Cedric Jacqueline _{1,

2} , Jocelyne Caillon _{1,

2} , Olivier Meyer ₃ , Eric Dailly _{4,

5} , Carl Simonsson ₃ , Vincent Lenaerts ₆ , Karim Asehnoune _{1,

7} , Amokrane Reghal ₂ , Gilles Potel _{1,

2}

Affiliation

S. aureus bone infections remain a therapeutic challenge, leading to long and expensive hospitalizations. Systemic antibiotic treatments are inconsistently effective due to insufficient penetration into the infectious site. In an osteomyelitis model, the ...

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