A Third Generation Potentially Bifunctional Trithiol Chelate, Its nat,1XXSb(III) Complex, and Selective Chelation of Radioantimony (119Sb) from Its Sn Target,Inorganic Chemistry

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A Third Generation Potentially Bifunctional Trithiol Chelate, Its nat,1XXSb(III) Complex, and Selective Chelation of Radioantimony (119Sb) from Its Sn Target
Inorganic Chemistry ( IF 4.3 ) Pub Date : 2021-10-04 , DOI: 10.1021/acs.inorgchem.1c01690
Aeli P Olson ₁ , Li Ma ₂ , Yutian Feng ₃ , Firouzeh Najafi Khosroshahi ₂ , Steven P Kelley ₂ , Eduardo Aluicio-Sarduy ₁ , Todd E Barnhart ₁ , Heather M Hennkens _{2,

4} , Paul A Ellison ₁ , Silvia S Jurisson ₂ , Jonathan W Engle _{1,

5}

Affiliation

The therapeutic potential of the Meitner-Auger- and conversion-electron emitting radionuclide ¹¹⁹Sb remains unexplored because of the difficulty of incorporating it into biologically targeted compounds. To address this challenge, we report the development of ¹¹⁹Sb production from electroplated tin cyclotron targets and its complexation by a novel trithiol chelate. The chelation reaction occurs in harsh solvent conditions even in the presence of large quantities of tin, which are necessary for production on small, low energy (16 MeV) cyclotrons. The ¹¹⁹Sb-trithiol complex has high stability and can be purified by HPLC. The third generation trithiol chelate and the analogous stable ^natSb-trithiol compound were synthesized and characterized, including by single-crystal X-ray diffraction analyses.

中文翻译：

第三代潜在的双功能三硫醇螯合物、其 nat、1XXSb(III) 配合物和放射性锑 (119Sb) 从其 Sn 靶材的选择性螯合

Meitner-Auger 和转换电子发射放射性核素¹¹⁹ Sb 的治疗潜力仍未探索，因为难以将其纳入生物靶向化合物中。为了应对这一挑战，我们报告了从电镀锡回旋加速器靶材生产¹¹⁹ Sb 的发展及其与新型三硫醇螯合物的络合。即使在存在大量锡的情况下，螯合反应也会在苛刻的溶剂条件下发生，这对于在小型低能量 (16 MeV) 回旋加速器上进行生产是必需的。¹¹⁹ Sb-三硫醇络合物稳定性高，可通过HPLC纯化。第三代三硫醇螯合物及类似的稳定^nat合成并表征了 Sb-三硫醇化合物，包括通过单晶 X 射线衍射分析。

更新日期：2021-10-18

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