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In Situ Functionalization of Cellulose with Zinc Pyrithione for Antimicrobial Applications
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2021-10-04 , DOI: 10.1021/acsami.1c14113 Neeta Kumari 1 , Sambit Nath Bhattacharya 2 , Shukla Das 3 , Shyama Datt 3 , Taru Singh 3 , Manjeet Jassal 1 , Ashwini K Agrawal 1
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2021-10-04 , DOI: 10.1021/acsami.1c14113 Neeta Kumari 1 , Sambit Nath Bhattacharya 2 , Shukla Das 3 , Shyama Datt 3 , Taru Singh 3 , Manjeet Jassal 1 , Ashwini K Agrawal 1
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Considering the public health demands for stronger and effective personal protective clothing, herein, antimicrobial fabrics using a known bacteriostatic and fungistatic drug zinc pyrithione (ZPT) have been reported. ZPT was synthesized in situ on cellulosic fabric, viscose (VC), using a zinc metal precursor and 2-mercaptopyridine-N-oxide as a ligand (VC-ZPT). For comparison, viscose was also phosphorylated (VP) before in situ functionalization with ZPT (VP-ZPT). Both approaches provided adequate protection from microbes; however, functionalization of cellulose with phosphate (VP) resulted in the formation of a linking group between cellulose and ZPT, which exhibited better uniformity of ZPT over the fabric surface and higher durability to washing. The functionalization was confirmed by inductively coupled plasma mass spectroscopy (ICP-MS), scanning electron microscopy (SEM), and Raman spectroscopy. Further, the bonding of phosphate with ZPT was confirmed by 31P solid-state NMR. The physical properties, such as appearance, bending length, and mechanical strength, of the treated fabrics remained unchanged. The antimicrobial activities of VP-ZPT with VC-ZPT were studied against Escherichia coli, Staphylococcus aureus, and Candida albicans, which were found to be effective until 20 laundry cycles in VP-ZPT. Additionally, VP-ZPT samples exhibited poor adherence of bacteria on the fabric surface. The functionalized fabrics may find applications for topical skin diseases in reducing the necessity of repeated use of antibiotic ointments.
中文翻译：
用吡啶硫酮锌原位功能化纤维素用于抗菌应用
考虑到公共卫生对更坚固和有效的个人防护服的需求，本文报道了使用已知的抑菌和抑菌药物吡啶硫酮锌 (ZPT) 的抗菌织物。ZPT 是在纤维素织物粘胶 (VC) 上原位合成的，使用锌金属前体和 2-巯基吡啶-N-氧化物作为配体 (VC-ZPT)。为了比较，粘胶在原位之前也被磷酸化（VP）使用 ZPT (VP-ZPT) 进行功能化。两种方法都提供了充分的微生物保护；然而，纤维素与磷酸盐 (VP) 的功能化导致纤维素和 ZPT 之间形成连接基团，这表现出 ZPT 在织物表面上的更好均匀性和更高的耐洗性。通过电感耦合等离子体质谱 (ICP-MS)、扫描电子显微镜 (SEM) 和拉曼光谱证实了功能化。此外，磷酸盐与ZPT的结合通过31 P固态NMR证实。处理后织物的外观、弯曲长度和机械强度等物理性能保持不变。研究了VP-ZPT与VC-ZPT对大肠杆菌的抗菌活性，金黄色葡萄球菌和白色念珠菌，在 VP-ZPT 中发现在 20 个洗衣周期之前有效。此外，VP-ZPT 样品在织物表面上表现出较差的细菌粘附性。功能化织物可用于局部皮肤病，以减少重复使用抗生素软膏的必要性。
更新日期：2021-10-13
中文翻译：
用吡啶硫酮锌原位功能化纤维素用于抗菌应用
考虑到公共卫生对更坚固和有效的个人防护服的需求，本文报道了使用已知的抑菌和抑菌药物吡啶硫酮锌 (ZPT) 的抗菌织物。ZPT 是在纤维素织物粘胶 (VC) 上原位合成的，使用锌金属前体和 2-巯基吡啶-N-氧化物作为配体 (VC-ZPT)。为了比较，粘胶在原位之前也被磷酸化（VP）使用 ZPT (VP-ZPT) 进行功能化。两种方法都提供了充分的微生物保护；然而，纤维素与磷酸盐 (VP) 的功能化导致纤维素和 ZPT 之间形成连接基团，这表现出 ZPT 在织物表面上的更好均匀性和更高的耐洗性。通过电感耦合等离子体质谱 (ICP-MS)、扫描电子显微镜 (SEM) 和拉曼光谱证实了功能化。此外，磷酸盐与ZPT的结合通过31 P固态NMR证实。处理后织物的外观、弯曲长度和机械强度等物理性能保持不变。研究了VP-ZPT与VC-ZPT对大肠杆菌的抗菌活性，金黄色葡萄球菌和白色念珠菌，在 VP-ZPT 中发现在 20 个洗衣周期之前有效。此外，VP-ZPT 样品在织物表面上表现出较差的细菌粘附性。功能化织物可用于局部皮肤病，以减少重复使用抗生素软膏的必要性。
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