Mechanistic Insight into the Design of Chemical Tools to Control Multiple Pathogenic Features in Alzheimer’s Disease,Accounts of Chemical Research

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Mechanistic Insight into the Design of Chemical Tools to Control Multiple Pathogenic Features in Alzheimer’s Disease
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2021-10-04 , DOI: 10.1021/acs.accounts.1c00457
Jiyeon Han ₁ , Zhi Du ₁ , Mi Hee Lim ₁

Affiliation

Alzheimer’s disease (AD) is the most common form of dementia and is characterized by memory loss and cognitive decline. Approximately 50 million people worldwide are suffering from AD and related dementias. Very recently, the first new drug targeting amyloid-β (Aβ) aggregates has been approved by the United States Food and Drug Administration, but its efficacy against AD is still debatable. Other available treatments temporarily relieve the symptoms of AD. The difficulty in discovering effective therapeutics for AD originates from its complicated nature, which results from the interrelated pathogenic pathways led by multiple factors. Therefore, to develop potent disease-modifying drugs, multiple pathological features found in AD should be fully elucidated.

中文翻译：

对控制阿尔茨海默病多种致病特征的化学工具设计的机械洞察

阿尔茨海默病 (AD) 是最常见的痴呆症，其特征是记忆力减退和认知能力下降。全世界大约有 5000 万人患有 AD 和相关的痴呆症。最近，第一个靶向淀粉样蛋白-β (Aβ) 聚集体的新药已获得美国食品和药物管理局的批准，但其对 AD 的疗效仍存在争议。其他可用的治疗方法可以暂时缓解 AD 的症状。发现 AD 有效治疗方法的困难源于其复杂性，这是由多种因素导致的相互关联的致病途径所致。因此，为了开发有效的疾病缓解药物，应充分阐明 AD 中发现的多种病理特征。

更新日期：2021-10-19

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