Expanding the horizon of research into the pathogenesis of the white matter diseases: Proceedings of the 2021 Annual Workshop of the Albert Research Institute for White Matter and Cognition,GeroScience

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Expanding the horizon of research into the pathogenesis of the white matter diseases: Proceedings of the 2021 Annual Workshop of the Albert Research Institute for White Matter and Cognition
GeroScience ( IF 5.3 ) Pub Date : 2021-10-04 , DOI: 10.1007/s11357-021-00461-8
Shawn N Whitehead ₁ , Askiel Bruno ₂ , Jeffrey M Burns ₃ , S Thomas Carmichael ₄ , Anna Csiszar _{5,

6} , Jodi D Edwards _{7,

8} , Fanny M Elahi ₉ , Giuseppe Faraco ₁₀ , Douglas B Gould ₁₁ , Deborah R Gustafson ₁₂ , Vladimir Hachinski ₁₃ , Gary Rosenberg ₁₄ , Farzaneh A Sorond ₁₅ , Andy Y Shih ₁₆ , Kai Hei Tse ₁₇ , Zoltan Ungvari _{5,

6} , Donna M Wilcock ₁₈ , Kristen L Zuloaga ₁₉ , Frank C Barone ₂₀

Affiliation

Department of Anatomy and Cell Biology, Western University, London, ON, N6A 3K7, Canada.
Department of Neurology, Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA.
Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA.
Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA.
Vascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
International Training Program in Geroscience, Doctoral School of Basic and Translational Medicine/Department of Translational Medicine, Semmelweis University, Budapest, Hungary.
University of Ottawa Heart Institute, Ottawa, Canada.
School of Epidemiology and Public Health, University of Ottawa, Ottawa, K1G 5Z3, Canada.
Memory and Aging Center, UCSF Weill Institute for Neurosciences, 675 Nelson Rising Lane, Suite 190, San Francisco, CA, 94158, USA.
Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, 10065, USA.
Departments of Ophthalmology and Anatomy, and Institute for Human Genetics, School of Medicine, University of California, San Francisco, 94143, USA.
Department of Neurology, Section for NeuroEpidemiology, State University of New York Downstate Health Sciences University, New York, Brooklyn, 11203, USA.
Department of Clinical Neurological Sciences, Western University, London, ON, N6A 5C1, Canada.
UNM Health Sciences Center, University of New Mexico, Albuquerque, NM, 87106, USA.
Department of Neurology, Northwestern University, Chicago, IL, USA.
Center for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute; Department of Pediatrics; Department of Bioengineering, University of Washington, Seattle, WA, USA.
Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Kowloon, Hong Kong.
Sanders-Brown Center on Aging; Department of Neurology, Department of Behavioral Science, University of Kentucky, Lexington, KY, 40536, USA.
Department of Neuroscience and Experimental Therapeutics, Albany Medical College, Albany, NY, 12208, USA.
Department of Neurology, SUNY Downstate Health Sciences University, Brooklyn, NY, 11203, USA.

White matter pathologies are critically involved in the etiology of vascular cognitive impairment–dementia (VCID), Alzheimer’s disease (AD), and Alzheimer’s disease and related diseases (ADRD), and therefore need to be considered a treatable target ( Roseborough A, Hachinski V, Whitehead S. White matter degeneration - a treatable target? Roseborough et al. JAMA Neurol [Internet]. 2020 Apr 27;77(7):793–4, [1] . To help address this often-missed area of research, several workshops have been sponsored by the Leo and Anne Albert Charitable Trust since 2015, resulting in the incorporation of “The Albert Research Institute for White Matter and Cognition” in 2020. The first annual “Institute” meeting was held virtually on March 3–4, 2021. The Institute provides a forum and workspace for communication and support of the advancement of white matter science and research to better understand the evolution and prevention of dementia. It serves as a platform for young investigator development, to introduce new data and debate biology mechanisms and new ideas, and to encourage and support new research collaborations and directions to clarify how white matter changes, with other genetic and health risk factors, contribute to cognitive impairment. Similar to previous Albert Trust–sponsored workshops (Barone et al. in J Transl Med 14:1–14, [2]; Sorond et al. in GeroScience 42:81–96, [3]), established expert investigators were identified and invited to present. Opportunities to attend and present were also extended by invitation to talented research fellows and younger scientists. Also, updates on institute-funded research collaborations were provided and discussed. The summary that follows is a synopsis of topics and discussion covered in the workshop.

中文翻译：

扩大白质疾病发病机制的研究视野：阿尔伯特白质与认知研究所 2021 年年度研讨会论文集

白质病理与血管性认知障碍痴呆 (VCID)、阿尔茨海默病 (AD) 和阿尔茨海默病及相关疾病 (ADRD) 的病因学密切相关，因此需要被视为可治疗的靶点 (Roseborough A, Hachinski V) , Whitehead S. 白质变性 - 一个可治疗的目标? Roseborough et al. JAMA Neurol [Internet]. 2020 Apr 27;77(7):793–4, [1] . 为了帮助解决这个经常被忽视的研究领域，自 2015 年以来，Leo 和 Anne Albert 慈善信托基金赞助了多次研讨会，最终于 2020 年成立了“阿尔伯特白质与认知研究所”。首次年度“研究所”会议于 3 月 3 日至 4 日以虚拟方式举行，2021。该研究所提供了一个论坛和工作空间，用于交流和支持白质科学研究的进步，以更好地了解痴呆症的演变和预防。它作为年轻研究者发展的平台，引入新数据和辩论生物学机制和新想法，并鼓励和支持新的研究合作和方向，以阐明白质变化以及其他遗传和健康风险因素如何导致认知障碍。与之前由 Albert Trust 赞助的研讨会类似（Barone 等人，发表于 J Transl Med 14:1–14，[2]；Sorond 等人，发表于 GeroScience 42:81–96，[3]），确定了既定的专家研究人员并受邀出席。还邀请才华横溢的研究员和年轻科学家提供了出席和演讲的机会。此外，还提供并讨论了研究所资助的研究合作的最新情况。以下摘要是研讨会涵盖的主题和讨论的概要。

更新日期：2021-10-06

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