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Scope, Limitations and Mechanistic Analysis of the HyperBTM-Catalyzed Acylative Kinetic Resolution of Tertiary Heterocyclic Alcohols**
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2021-10-04 , DOI: 10.1002/ejoc.202101111 Samuel M. Smith 1 , Mark D. Greenhalgh 2 , Taisiia Feoktistova 3 , Daniel M. Walden 3 , James E. Taylor 4 , David B. Cordes 5 , Alexandra M. Z. Slawin 5 , Paul Ha-Yeon Cheong 3 , Andrew David Smith 6
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2021-10-04 , DOI: 10.1002/ejoc.202101111 Samuel M. Smith 1 , Mark D. Greenhalgh 2 , Taisiia Feoktistova 3 , Daniel M. Walden 3 , James E. Taylor 4 , David B. Cordes 5 , Alexandra M. Z. Slawin 5 , Paul Ha-Yeon Cheong 3 , Andrew David Smith 6
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The isothiourea HyperBTM catalyzes the acylative kinetic resolution of a wide range of tertiary heterocyclic alcohols under mild conditions with high selectivity. The synthetic utility of the methodology has been demonstrated with the preparation of two bioactive targets. Kinetic analysis reveals a fractional reaction order with respect to the alcohol concentration.
中文翻译：
HyperBTM 催化的叔杂环醇酰基化动力学拆分的范围、局限性和机理分析**
异硫脲 HyperBTM 在温和条件下以高选择性催化多种叔杂环醇的酰化动力学拆分。该方法的合成效用已通过制备两个生物活性靶标得到证明。动力学分析揭示了关于醇浓度的分级反应顺序。
更新日期：2021-10-04
中文翻译：
HyperBTM 催化的叔杂环醇酰基化动力学拆分的范围、局限性和机理分析**
异硫脲 HyperBTM 在温和条件下以高选择性催化多种叔杂环醇的酰化动力学拆分。该方法的合成效用已通过制备两个生物活性靶标得到证明。动力学分析揭示了关于醇浓度的分级反应顺序。
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