In this study, we demonstrated the aggregation of liposome using ultrafast DNA photo-cross-linking with 3-cyanovinylcarbazole nucleoside (^CNVK). Liposomes are not only used in model experiments of cell membranes, but also are attracting attention as a carrier for drug delivery. The surface of liposomes can be modified with biomolecules such as peptides and DNA. So far, several studies have been conducted to control liposome aggregation by DNA, and it was found that oligoDNA (ODN) containing ^CNVK can photo-cross-link to pyrimidine bases in complementary strand using photoirradiation for a few seconds. Therefore, this DNA photo-cross-linking procedure was adapted for liposome aggregation.

中文翻译：

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含有超快 DNA 光交联剂的 DNA 修饰脂质体的光诱导聚集

在这项研究中，我们使用 3-氰基乙烯基咔唑核苷 ( ^CNV K) 的超快 DNA 光交联证明了脂质体的聚集。脂质体不仅用于细胞膜的模型实验，而且作为药物递送的载体也备受关注。脂质体的表面可以用生物分子如肽和DNA进行修饰。到目前为止，已经进行了几项研究来控制 DNA 的脂质体聚集，并且发现含有^CNV K 的寡聚 DNA (ODN)可以使用光照射几秒钟与互补链中的嘧啶碱基进行光交联。因此，这种 DNA 光交联程序适用于脂质体聚集。