Large-scale provocation studies identify maladaptive responses to ubiquitous aeroallergens as a correlate of severe allergic rhinoconjunctivitis and asthma,Allergy

当前位置： X-MOL 学术 › Allergy › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Large-scale provocation studies identify maladaptive responses to ubiquitous aeroallergens as a correlate of severe allergic rhinoconjunctivitis and asthma
Allergy ( IF 12.6 ) Pub Date : 2021-10-04 , DOI: 10.1111/all.15124
Alisha M Smith _{1,

2,

3,

4} , Robert M Ramirez ₅ , Nathan Harper _{1,

2} , Fabio Jimenez _{1,

2} , Anne P Branum _{1,

2} , Justin A Meunier _{1,

2} , Lavanya Pandranki _{1,

4} , Andrew Carrillo _{1,

2,

4} , Caitlyn Winter _{1,

6} , Lauryn Winter _{1,

6} , Cynthia G Rather ₅ , Daniel A Ramirez ₅ , Charles P Andrews ₅ , Marcos I Restrepo _{1,

4} , Diego J Maselli _{1,

4} , Jacqueline A Pugh ₁ , Robert A Clark _{1,

2,

3,

4} , Grace C Lee _{1,

7,

8} , Alvaro G Moreira _{1,

9} , Muthu Saravanan Manoharan _{1,

4} , Jason F Okulicz ₁₀ , Robert L Jacobs ₅ , Sunil K Ahuja _{1,

2,

3,

4,

11}

Affiliation

Veterans Administration Center for Personalized Medicine, South Texas Veterans Health Care System, San Antonio, Texas, USA.
Foundation for Advancing Veterans' Health Research, South Texas Veterans Health Care System, San Antonio, Texas, USA.
Department of Microbiology, Immunology & Molecular Genetics, UT Health San Antonio, San Antonio, Texas, USA.
Department of Medicine, UT Health San Antonio, San Antonio, Texas, USA.
Biogenics Research Chamber, San Antonio, Texas, USA.
Department of Pediatrics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
College of Pharmacy, The University of Texas at Austin, Austin, Texas, USA.
Pharmacotherapy Education and Research Center, School of Medicine, UT Health San Antonio, San Antonio, Texas, USA.
Division of Neonatology, Department of Pediatrics, UT Health San Antonio, San Antonio, Texas, USA.
Infectious Disease Service, San Antonio Military Medical Center, Fort Sam Houston, San Antonio, Texas, USA.
Department of Biochemistry and Structural Biology, UT Health San Antonio, San Antonio, Texas, USA.

Allergic asthma (AA) and allergic rhinoconjunctivitis (ARC) are common comorbid environmentally triggered diseases. We hypothesized that severe AA/ARC reflects a maladaptive or unrestrained response to ubiquitous aeroallergens.

中文翻译：