Breast cancer has become a serious threat to women's health. Cancer progression is mainly derived from resistance to apoptosis induced by procedures or therapies. Therefore, new drugs or models that can overcome apoptosis resistance should be identified. Ferroptosis is a recently identified mode of cell death characterized by excess reactive oxygen species-induced lipid peroxidation. Since ferroptosis is distinct from apoptosis, necrosis and autophagy, its induction successfully eliminates cancer cells that are resistant to other modes of cell death. Therefore, ferroptosis may become a new direction around which to design breast cancer treatment. Unfortunately, the complete appearance of ferroptosis in breast cancer has not yet been fully elucidated. Furthermore, whether ferroptosis inducers can be used in combination with traditional anti- breast cancer drugs is still unknown. Moreover, a summary of ferroptosis in breast cancer progression and therapy is currently not available. In this review, we discuss the roles of ferroptosis-associated modulators glutathione, glutathione peroxidase 4, iron, nuclear factor erythroid-2 related factor-2, superoxide dismutases, lipoxygenase and coenzyme Q in breast cancer. Furthermore, we provide evidence that traditional drugs against breast cancer induce ferroptosis, and that ferroptosis inducers eliminate breast cancer cells. Finally, we put forward prospect of using ferroptosis inducers in breast cancer therapy, and predict possible obstacles and corresponding solutions. This review will deepen our understanding of the relationship between ferroptosis and breast cancer, and provide new insights into breast cancer-related therapeutic strategies.

乳腺癌已成为对女性健康的严重威胁。癌症进展主要源于对程序或疗法诱导的细胞凋亡的抵抗。因此，应该确定可以克服细胞凋亡抗性的新药物或模型。铁死亡是最近发现的一种细胞死亡模式，其特征是过量的活性氧诱导的脂质过氧化。由于铁死亡不同于细胞凋亡、坏死和自噬，它的诱导成功地消除了对其他细胞死亡模式有抵抗力的癌细胞。因此，铁死亡可能成为设计乳腺癌治疗的新方向。不幸的是，尚未完全阐明乳腺癌中铁死亡的完整表现。此外，铁死亡诱导剂能否与传统的抗乳腺癌药物联合使用尚不清楚。此外，目前还没有关于乳腺癌进展和治疗中铁死亡的总结。在这篇综述中，我们讨论了铁死亡相关调节剂谷胱甘肽、谷胱甘肽过氧化物酶 4、铁、核因子 erythroid-2 相关因子 2、超氧化物歧化酶、脂氧合酶和辅酶 Q 在乳腺癌中的作用。此外，我们提供的证据表明，抗乳腺癌的传统药物可诱导铁死亡，而铁死亡诱导剂可消除乳腺癌细胞。最后，我们提出了在乳腺癌治疗中使用铁死亡诱导剂的前景，并预测了可能的障碍和相应的解决方案。