Multiple organ failure in critically ill patients is associated with poor prognosis, but biomarkers contributory to pathogenesis are unknown. Previous studies support a role for Fas cell surface death receptor (Fas)-mediated apoptosis in organ dysfunction. Our objectives were to test for associations between soluble Fas and multiple organ failure, identify protein quantitative trait loci, and determine associations between genetic variants and multiple organ failure.

中文翻译：

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FAS 中的单核苷酸变异与危重疾病中的器官衰竭和可溶性 Fas 细胞表面死亡受体相关。


危重患者的多器官衰竭与预后不良相关，但导致发病机制的生物标志物尚不清楚。先前的研究支持 Fas 细胞表面死亡受体 (Fas) 介导的细胞凋亡在器官功能障碍中的作用。我们的目标是测试可溶性 Fas 与多器官衰竭之间的关联，识别蛋白质数量性状位点，并确定遗传变异与多器官衰竭之间的关联。