Sleep disturbances and depression are closely linked and share a bidirectional relationship. These interconnections can inform the pathophysiology underlying each condition. Insomnia is an established and modifiable risk factor for depression, the treatment of which offers the critical opportunity to prevent major depressive episodes, a paradigm-shifting model for psychiatry. Identification of occult sleep disorders may also improve outcomes in treatment-resistant depression. Sleep alterations and manipulations may additionally clarify the mechanisms that underlie rapid-acting antidepressant therapies. Both sleep disturbance and depression are heterogeneous processes, and evolving standards in psychiatric research that consider the transdiagnostic components of each are more likely to lead to translational progress at their nexus. Emerging tools to objectively quantify sleep and its disturbances in the home environment offer great potential to advance clinical care and research, but nascent technologies require further advances and validation prior to widespread application at the interface of sleep and depression.

睡眠障碍和抑郁症密切相关，并具有双向关系。这些相互联系可以为每种病症的病理生理学提供信息。失眠是抑郁症的既定且可改变的风险因素，其治疗提供了预防重度抑郁发作的关键机会，这是精神病学的范式转换模型。识别隐匿性睡眠障碍也可能改善难治性抑郁症的结果。睡眠改变和操纵可能会进一步阐明速效抗抑郁治疗的基础机制。睡眠障碍和抑郁症都是异质过程，精神病学研究中不断发展的标准，考虑到每一种的跨诊断成分，更有可能导致它们之间的转化进展。