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C–H Amination Enabled [2+1+1+1] Annulation Reaction in Water: Access to Benzoxazoles
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2021-09-30 , DOI: 10.1002/ejoc.202100942 Huanfeng Jiang 1 , Fulin Chen 2 , Chuanle Zhu 2 , Zhiyi Yang 2 , Chi Liu 2 , Hao Zeng 2 , Wanqing Wu 2
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2021-09-30 , DOI: 10.1002/ejoc.202100942 Huanfeng Jiang 1 , Fulin Chen 2 , Chuanle Zhu 2 , Zhiyi Yang 2 , Chi Liu 2 , Hao Zeng 2 , Wanqing Wu 2
Affiliation
A novel and efficient strategy to prepare benzoxazoles through a [2+1+1+1] annulation of benzo-1,2-quinones, aldehydes, hydroxylamine hydrochloride and water is reported. The method is operationally simple and gram-scalable; it has a broad substrate scope and valuable functional group tolerance, and ensures high yields.
中文翻译:
C–H 胺化使水中的 [2+1+1+1] 环化反应:获得苯并恶唑
报道了一种通过苯并-1,2-醌、醛、盐酸羟胺和水的 [2+1+1+1] 环化制备苯并恶唑的新型有效策略。该方法操作简单且可扩展;它具有广泛的底物范围和宝贵的官能团耐受性,并确保高产量。
更新日期:2021-11-23
中文翻译:
C–H 胺化使水中的 [2+1+1+1] 环化反应:获得苯并恶唑
报道了一种通过苯并-1,2-醌、醛、盐酸羟胺和水的 [2+1+1+1] 环化制备苯并恶唑的新型有效策略。该方法操作简单且可扩展;它具有广泛的底物范围和宝贵的官能团耐受性,并确保高产量。