Abstract

In this paper, we explore the recent creation of “iBlastoids,” which are 3-D structures that resemble early human embryos prior to implantation which formed via self-organization of reprogrammed adult skin cells. We explore some of the ethical, philosophical, social, and regulatory issues related to this research, with focus particularly on what it means to “anticipate” research outcomes when using novel methods or when serendipitous discoveries are made. We defend the need for reflexive, anticipatory, and deliberative ethical and conceptual work by researchers working in emerging and contentious research domains, in collaboration with interdisciplinary scholars, as well as regulators, funders, and publics.

 抽象的

在本文中，我们探索了最近创建的“iBlastoids”，它是一种类似于植入前早期人类胚胎的 3D 结构，是通过重新编程的成人皮肤细胞的自组织形成的。我们探讨了与这项研究相关的一些伦理、哲学、社会和监管问题，特别关注在使用新颖方法或偶然发现时“预期”研究结果意味着什么。我们捍卫在新兴和有争议的研究领域工作的研究人员与跨学科学者以及监管机构、资助者和公众合作进行反思性、预期性和深思熟虑的伦理和概念工作的必要性。