Electrochemical Functionalization of Imidazopyridine and Indazole: An Overview,Advanced Synthesis & Catalysis

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Electrochemical Functionalization of Imidazopyridine and Indazole: An Overview
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2021-10-01 , DOI: 10.1002/adsc.202100981
Debashis Ghosh ₁ , Sumit Ghosh ₂ , Alakananda Hajra ₂

Affiliation

Electrochemical synthesis offers a mild, simple, and efficient tool for the preparation of interesting and useful molecules, thus eluding severe chemical oxidizing and reducing agents used in conventional synthetic methods. In particular, electrochemical Câˆ’H activation is expected to play an important role in the direct functionalization of heterocyclic compounds. Over the past few decades, the research interest in imidazopyridine and indazole has increased significantly due to their multipurpose uses in medicinal and industrial chemistry. Therefore, structural modification of these heterocycles using electro-oxidation has become one of the important research topics among synthetic organic chemistry in recent time. This review provides a comprehensive discussion of electrochemical functionalization of indazoles and imidazopyridines published so far. A summary of the current challenges and the future direction for the development of efficient and green electrochemical methods for functionalization of these heterocycles is also presented.

中文翻译：

咪唑并吡啶和吲唑的电化学功能化：概述

电化学合成为制备有趣且有用的分子提供了一种温和、简单且有效的工具，从而避免了常规合成方法中使用的严重化学氧化剂和还原剂。特别是，电化学 C∼'H 活化有望在杂环化合物的直接功能化中发挥重要作用。在过去的几十年中，由于咪唑并吡啶和吲唑在药物和工业化学中的多用途用途，对它们的研究兴趣显着增加。因此，利用电氧化对这些杂环进行结构修饰已成为近年来合成有机化学的重要研究课题之一。这篇综述对迄今为止发表的吲唑和咪唑并吡啶的电化学功能化进行了全面讨论。还概述了开发用于这些杂环官能化的高效绿色电化学方法的当前挑战和未来方向。

更新日期：2021-11-23

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