当前位置: X-MOL 学术Analyst › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Investigation of the effect of an octopole electric field on a linear ion trap and an asymmetric semi-circular linear ion trap analyzer
Analyst ( IF 3.6 ) Pub Date : 2021-09-18 , DOI: 10.1039/d1an01604k
Fuxing Xu 1 , Weimin Wang 1 , Xinhua Dai 2 , Xiang Fang 2 , Chuan-Fan Ding 1
Affiliation  

Linear ion trap mass analyzer could improve analytical performance compared to the traditional three-dimensional ion trap. In this study, a systematic investigation of the effect of octopole field on the performance of linear quadrupole ion trap was studied by both theoretical simulations and experiments. An asymmetric semi-circular linear ion trap (AsC-LIT) analyzer was designed and tested based on the theoretical results. The AsC-LIT consists of one pair of larger semi-circular rods with radius Ry and one pair of smaller semi-circular rods with radius Rx (Ry > Rx) in the cross section for introducing the quantitative octopole field. The analytical performances of these simplified AsC-LITs with different amounts of octopole fields were carefully investigated using both theoretical simulations and experimental validation. Experimental results showed that it could have a mass resolution of 1645 at m/z 175 (arginine); furthermore, the low mass cutoff and CID efficiency can be significantly improved when some positive octopole is added. The simulative results indicated that 2.56% octopole component was the best choice for achieving higher analytical performances. The theoretical and experimental studies of this work could certainly enrich the knowledge of a higher order electric field effect on the linear ion trap, furthermore, the simple geometric design and performance characteristics of this new AsC-LIT make it particularly attractive in the development of miniaturized mass spectrometers.

中文翻译:

研究八极电场对线性离子阱和非对称半圆形线性离子阱分析仪的影响

与传统的三维离子阱相比,线性离子阱质量分析器可以提高分析性能。在这项研究中,通过理论模拟和实验研究了八极杆场对线性四极杆离子阱性能的影响的系统研究。基于理论结果设计并测试了非对称半圆形线性离子阱(AsC-LIT)分析仪。AsC-LIT 由一对半径为R y的较大半圆棒和一对半径为R x的较小半圆棒组成(R y > R x) 在用于引入定量八极子场的横截面中。使用理论模拟和实验验证仔细研究了这些具有不同数量的八极杆场的简化 AsC-LIT 的分析性能。实验结果表明,它在m / z处具有 1645 的质量分辨率175(精氨酸);此外,当添加一些正八极杆时,可以显着提高低质量截断和 CID 效率。模拟结果表明,2.56% 的八极杆组件是实现更高分析性能的最佳选择。这项工作的理论和实验研究肯定会丰富对线性离子阱的高阶电场效应的知识,此外,这种新型 AsC-LIT 的简单几何设计和性能特征使其在小型化的发展中特别有吸引力。质谱仪。
更新日期:2021-10-01
down
wechat
bug