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Ophthalmic sensing technologies for ocular disease diagnostics
Analyst ( IF 3.6 ) Pub Date : 2021-09-24 , DOI: 10.1039/d1an01244d Yuqi Shi 1 , Nan Jiang 2 , Priyanka Bikkannavar 3 , M Francesca Cordeiro 3, 4 , Ali K Yetisen 1
Analyst ( IF 3.6 ) Pub Date : 2021-09-24 , DOI: 10.1039/d1an01244d Yuqi Shi 1 , Nan Jiang 2 , Priyanka Bikkannavar 3 , M Francesca Cordeiro 3, 4 , Ali K Yetisen 1
Affiliation
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Point-of-care diagnosis and personalized treatments are critical in ocular physiology and disease. Continuous sampling of tear fluid for ocular diagnosis is a need for further exploration. Several techniques have been developed for possible ophthalmological applications, from traditional spectroscopies to wearable sensors. Contact lenses are commonly used devices for vision correction, as well as for other therapeutic and cosmetic purposes. They are increasingly being developed into ocular sensors, being used to sense and monitor biochemical analytes in tear fluid, ocular surface temperature, intraocular pressure, and pH value. These sensors have had success in detecting ocular conditions, optimizing pharmaceutical treatments, and tracking treatment efficacy in point-of-care settings. However, there is a paucity of new and effective instrumentation reported in ophthalmology. Hence, this review will summarize the applied ophthalmic technologies for ocular diagnostics and tear monitoring, including both conventional and biosensing technologies. Besides applications of smart readout devices for continuous monitoring, targeted biomarkers are also discussed for the convenience of diagnosis of various ocular diseases. A further discussion is also provided for future aspects and market requirements related to the commercialization of novel types of contact lens sensors.
中文翻译：
用于眼部疾病诊断的眼科传感技术
即时诊断和个性化治疗对眼部生理和疾病至关重要。泪液的连续采样用于眼部诊断是需要进一步探索的。已经为可能的眼科应用开发了多种技术，从传统的光谱学到可穿戴传感器。隐形眼镜是视力矫正以及其他治疗和美容目的的常用设备。它们越来越多地被开发成眼部传感器，用于检测和监测泪液中的生化分析物、眼表温度、眼压和 pH 值。这些传感器在检测眼部状况、优化药物治疗和跟踪即时护理环境中的治疗效果方面取得了成功。然而，眼科中很少有新的有效仪器的报道。因此，本综述将总结应用于眼部诊断和泪液监测的眼科技术，包括传统和生物传感技术。除了用于连续监测的智能读出设备的应用外，还讨论了靶向生物标志物，以方便诊断各种眼部疾病。还提供了与新型隐形眼镜传感器商业化相关的未来方面和市场需求的进一步讨论。为了方便各种眼部疾病的诊断，还讨论了靶向生物标志物。还提供了与新型隐形眼镜传感器商业化相关的未来方面和市场需求的进一步讨论。为了方便各种眼部疾病的诊断，还讨论了靶向生物标志物。还提供了与新型隐形眼镜传感器商业化相关的未来方面和市场需求的进一步讨论。
更新日期：2021-09-30
中文翻译：
用于眼部疾病诊断的眼科传感技术
即时诊断和个性化治疗对眼部生理和疾病至关重要。泪液的连续采样用于眼部诊断是需要进一步探索的。已经为可能的眼科应用开发了多种技术，从传统的光谱学到可穿戴传感器。隐形眼镜是视力矫正以及其他治疗和美容目的的常用设备。它们越来越多地被开发成眼部传感器，用于检测和监测泪液中的生化分析物、眼表温度、眼压和 pH 值。这些传感器在检测眼部状况、优化药物治疗和跟踪即时护理环境中的治疗效果方面取得了成功。然而，眼科中很少有新的有效仪器的报道。因此，本综述将总结应用于眼部诊断和泪液监测的眼科技术，包括传统和生物传感技术。除了用于连续监测的智能读出设备的应用外，还讨论了靶向生物标志物，以方便诊断各种眼部疾病。还提供了与新型隐形眼镜传感器商业化相关的未来方面和市场需求的进一步讨论。为了方便各种眼部疾病的诊断，还讨论了靶向生物标志物。还提供了与新型隐形眼镜传感器商业化相关的未来方面和市场需求的进一步讨论。为了方便各种眼部疾病的诊断，还讨论了靶向生物标志物。还提供了与新型隐形眼镜传感器商业化相关的未来方面和市场需求的进一步讨论。
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