Hip and knee osteoarthritis (OA) are leading causes of global disability. Most research to date has focused on the knee, with results often extrapolated to the hip, and this extends to treatment recommendations in clinical guidelines. Extrapolating results from research on knee OA may limit our understanding of disease characteristics specific to hip OA, thereby constraining development and implementation of effective treatments. This review highlights differences between hip and knee OA with respect to prevalence, prognosis, epigenetics, pathophysiology, anatomical and biomechanical factors, clinical presentation, pain and non-surgical treatment recommendations and management.

髋关节和膝关节骨关节炎 (OA) 是全球残疾的主要原因。迄今为止，大多数研究都集中在膝盖上，结果通常外推到臀部，这延伸到临床指南中的治疗建议。从膝关节 OA 的研究中推断结果可能会限制我们对髋关节 OA 特有的疾病特征的理解，从而限制有效治疗的开发和实施。本综述强调了髋关节和膝关节 OA 在患病率、预后、表观遗传学、病理生理学、解剖学和生物力学因素、临床表现、疼痛和非手术治疗建议和管理方面的差异。