This editorial paper presents the papers published in a special issue devoted to the modeling and simulation of mutating virus pandemics in a globally connected world. The presentation is proposed in three parts. First, motivations and objectives are presented according to the idea that mathematical models should go beyond deterministic population dynamics by considering the multiscale, heterogeneous features of the complex system under consideration. Subsequently, the contents of the papers in this issue are presented referring to the aforementioned complexity features. Finally, a critical analysis of the overall contents of the issue is proposed, with the aim of providing a forward look to research perspectives.

这篇社论论文介绍了发表在特刊上的论文，这些论文致力于在全球互联的世界中对变异病毒大流行进行建模和模拟。介绍分为三个部分。首先，根据数学模型应该通过考虑所考虑的复杂系统的多尺度、异质特征来超越确定性种群动态的想法，提出动机和目标。随后，结合上述复杂性特征，介绍本期论文的内容。最后，提出了对该问题整体内容的批判性分析，旨在为研究视角提供前瞻性。