3D-Printed Multifunctional Polyetheretherketone Bone Scaffold for Multimodal Treatment of Osteosarcoma and Osteomyelitis,ACS Applied Materials & Interfaces

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3D-Printed Multifunctional Polyetheretherketone Bone Scaffold for Multimodal Treatment of Osteosarcoma and Osteomyelitis
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2021-09-29 , DOI: 10.1021/acsami.1c10898
Ce Zhu _{1,

2} , Miaomiao He ₁ , Dan Sun ₃ , Yong Huang ₁ , Leizhen Huang ₁ , Meixuan Du ₁ , Jingcheng Wang ₁ , Juehan Wang ₁ , Zhongyang Li ₁ , Bowen Hu ₁ , Yueming Song ₁ , Yubao Li ₁ , Ganjun Feng ₁ , Limin Liu ₁ , Li Zhang ₁

Affiliation

In this work, we developed the first 3D-printed polyetheretherketone (PEEK)-based bone scaffold with multi-functions targeting challenging bone diseases such as osteosarcoma and osteomyelitis. A 3D-printed PEEK/graphene nanocomposite scaffold was deposited with a drug-laden (antibiotics and/or anti-cancer drugs) hydroxyapatite coating. The graphene nanosheets within the scaffold served as effective photothermal agents that endowed the scaffold with on-demand photothermal conversion function under near-infrared laser irradiation. The bioactive hydroxyapatite coating significantly boosted the stem cell proliferation in vitro and promoted new bone growth in vivo. The presence of antibiotics and anti-cancer drugs enabled eradication of drug-resistant bacteria and ablation of osteosarcoma cancer cells, the treatment efficacy of which can be further enhanced by on-demand laser-induced heating. The promising results demonstrate the strong potential of our multi-functional scaffold in applications such as bone defect repair and multimodal treatment of osteosarcoma and osteomyelitis.

中文翻译：

3D打印多功能聚醚醚酮骨支架用于骨肉瘤和骨髓炎的多模式治疗

在这项工作中，我们开发了第一个基于 3D 打印聚醚醚酮 (PEEK) 的多功能骨支架，针对骨肉瘤和骨髓炎等具有挑战性的骨疾病。 3D 打印的 PEEK/石墨烯纳米复合材料支架上沉积有载药（抗生素和/或抗癌药物）羟基磷灰石涂层。支架内的石墨烯纳米片作为有效的光热剂，赋予支架在近红外激光照射下按需光热转换功能。生物活性羟基磷灰石涂层显着促进体外干细胞增殖并促进体内新骨生长。抗生素和抗癌药物的存在使得能够根除耐药细菌并消融骨肉瘤癌细胞，通过按需激光诱导加热可以进一步增强治疗效果。这些令人鼓舞的结果证明了我们的多功能支架在骨缺损修复以及骨肉瘤和骨髓炎的多模式治疗等应用中的巨大潜力。

更新日期：2021-10-13

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