Glaucoma is the leading cause of irreversible blindness. It is estimated that as many as 3.2 million people worldwide experience blindness due to glaucoma, including open-angle glaucoma (OAG). Until now, there is no definite mechanism related to the incidence of OAG. However, increased intraocular pressure (IOP) is considered to be the most important risk factor. Several current studies show that there is a significant relationship between hypertension (HTN) and IOP. In particular, several epidemiological studies have shown that an increase in systemic blood pressure (BP) is associated with an increase in IOP. However, several studies report that high BP provides a protective effect at a young age against the incidence of OAG. Therefore, this literature aims to explore the effect of HTN on the incidence of OAG. In this review, search for the literature using keywords that match the topic, then a gradual screening was carried out with the predetermined eligibility criteria. From 3711 studies, 16 studies matched the criteria having a total sample size of 72 212 and then a quantitative meta-analysis was conducted. The results showed a risk ratio of 1.69 (95% CI 1.50 to 1.90) in the HTN group. However, from our qualitative synthesis, we found that people who have an unstable diastolic blood pressure (DBP), either high or low, are both able to increase the risk of OAG events. In conclusion, we found that HTN was able to increase the risk of OAG and DBP instability, whether high or low, can also increase the risk of OAG incidence. No data are available.

中文翻译：

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高血压作为开角型青光眼危险因素的作用：系统评价和荟萃分析

青光眼是导致不可逆失明的主要原因。据估计，全球有多达 320 万人因青光眼（包括开角型青光眼 (OAG)）而失明。迄今为止，尚无明确的与OAG发生相关的机制。然而，眼内压（IOP）升高被认为是最重要的危险因素。目前的几项研究表明，高血压 (HTN) 和 IOP 之间存在显着关系。特别是，一些流行病学研究表明，全身血压（BP）升高与眼压升高相关。然而，一些研究报告称，高血压在年轻时对预防 OAG 的发生具有保护作用。因此，本文献旨在探讨HTN对OAG发生率的影响。在该综述中，使用与主题匹配的关键词搜索文献，然后按照预定的资格标准进行逐步筛选。从 3711 项研究中，有 16 项研究符合标准，总样本量为 72 212，然后进行定量荟萃分析。结果显示，HTN 组的风险比为 1.69（95% CI 1.50 至 1.90）。然而，从我们的定性综合来看，我们发现舒张压 (DBP) 不稳定的人，无论高还是低，都会增加 OAG 事件的风险。总之，我们发现 HTN 能够增加 OAG 的风险，而 DBP 不稳定，无论高还是低，也能增加 OAG 发生的风险。无可用数据。