Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy,Chemical Reviews

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Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy
Chemical Reviews ( IF 51.4 ) Pub Date : 2021-09-28 , DOI: 10.1021/acs.chemrev.1c00381
Thanh Chung Pham ₁ , Van-Nghia Nguyen ₂ , Yeonghwan Choi ₁ , Songyi Lee _{1,

3} , Juyoung Yoon ₂

Affiliation

This review presents a robust strategy to design photosensitizers (PSs) for various species. Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the use of light combined with a light-activated chemical, referred to as a PS. Attractively, PDT is one of the alternatives to conventional cancer treatment due to its noninvasive nature, high cure rates, and low side effects. PSs play an important factor in photoinduced reactive oxygen species (ROS) generation. Although the concept of photosensitizer-based photodynamic therapy has been widely adopted for clinical trials and bioimaging, until now, to our surprise, there has been no relevant review article on rational designs of organic PSs for PDT. Furthermore, most of published review articles in PDT focused on nanomaterials and nanotechnology based on traditional PSs. Therefore, this review aimed at reporting recent strategies to develop innovative organic photosensitizers for enhanced photodynamic therapy, with each example described in detail instead of providing only a general overview, as is typically done in previous reviews of PDT, to provide intuitive, vivid, and specific insights to the readers.

中文翻译：

开发用于增强光动力疗法的创新光敏剂的最新策略

本综述提出了一种为各种物种设计光敏剂 (PS) 的稳健策略。光动力疗法 (PDT) 是一种基于光化学的治疗方法，涉及使用光与光激活化学物质（称为 PS）的结合。有吸引力的是，PDT 是传统癌症治疗的替代方法之一，因为它具有无创性、高治愈率和低副作用。PSs 在光诱导活性氧 (ROS) 生成中起重要作用。尽管基于光敏剂的光动力疗法的概念已广泛应用于临床试验和生物成像，但令我们惊讶的是，到目前为止，还没有关于合理设计用于 PDT 的有机 PSs 的相关综述文章。此外，在 PDT 上发表的大多数评论文章都集中在基于传统 PS 的纳米材料和纳米技术上。

更新日期：2021-11-10

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