Background: It is substantiated that LncRNAs are associated with carcinoma progression. OIP5- AS1 is a tumor-related carcinoma suppressor lncRNA, previously discovered in zebrafish, which is involved in the progression of a variety of cancers, has a regulatory effect on carcinoma, and interacts with miRNA and other biomolecules to affect the physiological and pathological processes of carcinoma cells. This article will discuss the effect of OIP5-AS1 in various cancers and its regulatory mechanism.

Methods: This paper summarized and analyzed OIP5-AS1, which functions on the germination and progression of carcinoma and its regulatory mechanism. Meanwhile, the related research was retrieved and collected by the PubMed system.

Result: OIP5-AS1 is overexpressed in various tumors, which regulates and controls tumor growth and participates in tumor progression, including breast carcinoma, ovarian carcinoma, cervical carcinoma, lung carcinoma, laryngeal squamous cell gastric carcinoma and hepatocellular carcinoma. The research evidence proves that OIP5-AS1 takes part in carcinoma proliferation, growth, migration, invasion, and apoptosis.

Conclusion: OIP5-AS1 probably can be an effective biomarker or a potential therapeutic target in multiple tumors.

背景：已证实 LncRNA 与癌症进展有关。OIP5-AS1是一种肿瘤相关抑癌基因lncRNA，此前在斑马鱼中发现，参与多种癌症的进展，对癌有调节作用，与miRNA等生物分子相互作用，影响生理和病理过程的癌细胞。本文将讨论OIP5-AS1在各种癌症中的作用及其调控机制。

方法：本文总结分析了OIP5-AS1在癌的萌发和进展中的作用及其调控机制。同时，通过PubMed系统检索和收集相关研究。

结果：OIP5-AS1在多种肿瘤中过表达，调节和控制肿瘤生长并参与肿瘤进展，包括乳腺癌、卵巢癌、宫颈癌、肺癌、喉鳞状细胞胃癌和肝细胞癌。研究证据证明OIP5-AS1参与了癌的增殖、生长、迁移、侵袭和凋亡。

结论：OIP5-AS1可能是多种肿瘤的有效生物标志物或潜在治疗靶点。