Target site pharmacokinetics of meropenem: Measurement in human explanted lung tissue by bronchoalveolar lavage, microdialysis and homogenized lung tissue,Antimicrobial Agents and Chemotherapy

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Target site pharmacokinetics of meropenem: Measurement in human explanted lung tissue by bronchoalveolar lavage, microdialysis and homogenized lung tissue
Antimicrobial Agents and Chemotherapy ( IF 4.1 ) Pub Date : 2021-09-27 , DOI: 10.1128/aac.01564-21
Michael Paal ₁ , Christina Scharf ₂ , Ann Katrin Denninger ₂ , Luis Ilia ₃ , Charlotte Kloft ₃ , Nikolaus Kneidinger ₄ , Uwe Liebchen _{2,

3} , Sebastian Michel ₅ , Christian Schneider ₆ , Sebastian Schröpf ₇ , Carina Schuster ₁ , Michael Vogeser ₁ , Ferdinand Weinelt _{3,

8} , Johannes Zander _{1,

9} , Michael Zoller ₂ , Ines Schroeder ₂

Affiliation

Objectives: Pneumonia is one of the most common infections in intensive care patients, and it is often treated with beta-lactam antibiotics. Even if therapeutic drug monitoring in blood is available, it is unclear whether sufficient concentrations are ...

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